Aflatoxin and dimethyl sulfoxide influence on radiomanganese distribution and retention in neonate mice

Journal Article · Sun Jan 01 00:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530521· OSTI ID:6000536

Thompson, J S; Llewellyn, G C

The LD50 (7 d) for aflatoxin B/sub 1/ (AFB/sub 1/) in CD-1 neonate mice (3.1 g; 5 d of age) was determined to be 13.3 mg/kg. The vehicle was dimethyl sulfoxide (DMSO), given intraperitoneally, at 0.01 ml/animal (7 mg/kg). The solvent was nontoxic and caused no significant change in body weight in animals during an 11-d experimental period (17 d of age). Aflatoxin B/sub 1/ at 5.0 mg/kg and above caused reduced body weight gain. DMSO animals had a mean loss of more than 17% of the radiolabel over a 9-d period. Aflatoxin treatments reversed the DMSO loss of /sup 54/Mn in a concentration-related fashion, and generally, AFB/sub 1/ caused a conservation of the radioisotope. The radiolabel was redistributed into the following organs/tissues: liver > brain > bone > muscle = lungs > blood. Aflatoxin-treated animals showed a twofold increase of radiolabel in the liver as compared to controls. The DMSO itself failed to influence /sup 54/Mn influx into the liver. In general, control neonate mice, by 17 d of age, were retaining and redistributing the /sup 54/MnCl/sub 2/ and had not reached the time for sudden emergence of excretion common in rodents. DMSO was found not to be the most satisfactory solvent to use in the administration of aflatoxins, especially when manganese metabolism is being studied. Generally, both DMSO and AFB/sub 1/ influenced radiomanganese distribution, DMSO having a substantial influence. 27 references, 3 figures, 2 tables.

• Research Organization: Virginia Commonwealth Univ., Richmond
• OSTI ID: 6000536
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 13:4-6
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
AFLATOXIN
TOXICITY
MANGANESE 54
METABOLISM
RETENTION
TISSUE DISTRIBUTION
ANIMAL GROWTH
BLOOD
BRAIN
DMSO
EXPERIMENTAL DATA
INHIBITION
LIVER
LUNGS
MICE
MUSCLES
NEONATES
RESPONSE MODIFYING FACTORS
SKELETON
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
DATA
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
GROWTH
INFORMATION
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MANGANESE ISOTOPES
MATERIALS
NERVOUS SYSTEM
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SULFOXIDES
TOXIC MATERIALS
TOXINS
VERTEBRATES
550501* - Metabolism- Tracer Techniques