Enzymes and isoenzymes in pathogenesis and diagnosis

Book · Thu Jan 01 00:00:00 EST 1987

OSTI ID:5995532

Goldberg, D M; Werner, M; Zaidman, J L

This book, based on 19 review articles discusses how enzymes and isoenzymes can be used in diagnosis, and the role they play in the pathogenesis of disease. The opening reports concentrate on the digestive system. Topics covered are advances in the diagnostic use of alkaline phosphatase isoenzymes, enzymes of value in pancreatic disease, and the modulation by steroids of gamma-glutamyltransferase in fetal hepatocytes. Advances are described such as the multiplicity of enzyme defects at the root of common inherited metabolic diseases. Newer applications of enzymology are shown, as in the role of purine-related enzymes in leukemia and immunodeficiency states. The role of enzymes in metabolic abnormalities such as oxylate formation, disorders of peroxisomal metabolism, hyperphenylalaninemia, and methemoglobinemia is explored.

• OSTI ID: 5995532
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
ENZYMES
DIAGNOSTIC USES
METABOLISM
ISOENZYMES
METABOLIC DISEASES
PATHOGENESIS
ALKALINE PHOSPHATASE
BIOASSAY
BIOLOGICAL MARKERS
DIAGNOSIS
DISEASES
ETIOLOGY
GENETICS
HEREDITARY DISEASES
LEUKEMIA
LIVER
PANCREAS
STRUCTURE-ACTIVITY RELATIONSHIPS
TRANSFERASES
BIOLOGY
BODY
DIGESTIVE SYSTEM
ENDOCRINE GLANDS
ESTERASES
GLANDS
HEMIC DISEASES
HYDROLASES
NEOPLASMS
ORGANS
PHOSPHATASES
USES
550600* - Medicine
550200 - Biochemistry