Pathophysiologic assessment of left ventricular hypertrophy and strain in asymptomatic patients with essential hypertension

Journal Article · Mon May 01 00:00:00 EDT 1989 · J. Am. Coll. Cardiol.; (United States)

DOI:https://doi.org/10.1016/0735-1097(89)90314-8· OSTI ID:5989637

Pringle, S D; Macfarlane, P W; McKillop, J H; Lorimer, A R; Dunn, F G

To investigate the significance of the electrocardiographic (ECG) pattern of left ventricular hypertrophy and strain, two groups of asymptomatic patients with essential hypertension were compared. The patients were similar in terms of age, smoking habit, serum cholesterol and blood pressure levels, but differed in the presence (Group I, n = 23) or absence (Group II, n = 23) of the ECG pattern of left ventricular hypertrophy and strain. Group I patients had significantly more episodes of exercise-induced ST segment depression (14 versus 4, p less than 0.05) and reversible thallium perfusion abnormalities (11 of 23 versus 3 of 23, p less than 0.05) despite similar exercise capacity and absence of chest pain. Nonsustained ventricular tachycardia was detected on 24 h ambulatory ECG monitoring in two patients in Group I, but no patient in Group II. Coronary arteriography performed in 20 Group I patients demonstrated significant coronary artery disease in 8 patients. This study has shown that there is a subgroup of hypertensive patients with ECG left ventricular hypertrophy and strain who have covert coronary artery disease. This can be detected by thallium perfusion scintigraphy, and may contribute to the increased risk known to be associated with this ECG abnormality.

• Research Organization: Univ. Department of Medical Cardiology, Glasgow (Scotland)
• OSTI ID: 5989637
• Journal Information: J. Am. Coll. Cardiol.; (United States), Vol. 13:6
• Country of Publication: United States
• Language: English

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