Effect of histamine and H/sub 1/- and H/sub 2/-agonists on the fractional outflow of radioactivity from the rat vas deferens and preloaded with (/sup 3/H)-noradrenaline

Journal Article · Mon Dec 20 00:00:00 EST 1982 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(82)90671-3· OSTI ID:5983735

MacIntosh, C M; Vohra, M M

Histamine and relatively selective H/sub 1/- and H/sub 2/-receptor agonists caused a concentration-dependent increase in the fractional outflow of radioactivity from the rat isolated vas deferens preloaded with labelled noradrenaline. The evoked fractional outflow of radioactivity was not preferentially associated with either H/sub 1/- or H/sub 2/-selective agonists, nor was it related to the known potencies of the agonists within each group. The evoked fractional outflow caused by all compounds studied was independent of the extracellular Ca/sup 2 +/ concentration. The study cautions against ascribing all the effects of histamine analogs to their respective histamine receptor stimulation.

• OSTI ID: 5983735
• Journal Information: Life Sci.; (United States), Vol. 31:25, Issue 25
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
HISTAMINE
BIOLOGICAL EFFECTS
NORADRENALINE
BIOCHEMISTRY
CALCIUM COMPOUNDS
CATIONS
MALE GENITALS
RATS
RECEPTORS
TRITIUM COMPOUNDS
ADRENAL HORMONES
ALKALINE EARTH METAL COMPOUNDS
AMINES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZOLES
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHARGED PARTICLES
CHEMISTRY
DRUGS
HETEROCYCLIC COMPOUNDS
HORMONES
IMIDAZOLES
IONS
LABELLED COMPOUNDS
MAMMALS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
551001 - Physiological Systems- Tracer Techniques