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Title: Effect of sucralfate on gastric emptying in duodenal ulcer patients

Duodenal ulcer (DU) patients may have accelerated gastric emptying (GE) suggesting that there is an increase in unbuffered gastric acid reaching the duodenum contributing to DU disease. Aluminum-containing antacids were shown to delay GE. The authors' aim was to investigate whether another aluminum-containing compound, Sucralfate, affects GE in normal and DU patients. Nine normal volunteers and 10 patients with documented DU disease were studied. For each test the subject ingested a meal composed of chicken liver Tc-99m-S-C mixed with beef stew and eaten with 4 oz. of water labelled with 100..mu..Ci of III-in-DTPA. On two separate days, subjects received 1 gram of Sucralfate (190 mg of aluminum per gram) or placebo in a randomized double-blind fashion one hour prior to the test meal. GE of liquids and solids in normal subjects was not significantly changed by Sucralfate. Sucralfate in the DU patients significantly slowed liquid emptying in the initial 40 min and solid food throughout the study compared to placebo (p<0.05). This paper summarizes that; GE of solids but not liquids is accelerated in DU patients compared to normal subjects; and sucralfate delays GE of both liquid and solid components of a meal in DU patients but has no effectmore » on GE in normals. The authors conclude that a slowing of gastric emptying possibly mediated by aluminum ions, may be one mechanism by which Sucralfate enhances healing and decreases recurrence of DU.« less
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
5976016
Report Number(s):
CONF-850611-
Journal ID: CODEN: JNMEA; TRN: 87-039214
Resource Type:
Conference
Resource Relation:
Journal Name: J. Nucl. Med.; (United States); Journal Volume: 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
Research Org:
Depts. of Medicine and Nuclear Medicine, Yale Univ.
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; STOMACH; DYNAMIC FUNCTION STUDIES; PATHOLOGICAL CHANGES; TECHNETIUM 99; DIAGNOSTIC USES; UPTAKE; ULCERS; HEALING; ALUMINIUM COMPOUNDS; DIGESTION; DIGESTIVE SYSTEM DISEASES; ORAL ADMINISTRATION; PATIENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL RECOVERY; BODY; DIGESTIVE SYSTEM; DISEASES; GASTROINTESTINAL TRACT; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; RECOVERY; TECHNETIUM ISOTOPES; USES; YEARS LIVING RADIOISOTOPES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics; 551001 -- Physiological Systems-- Tracer Techniques; 550901 -- Pathology-- Tracer Techniques