Preliminary results of Tc-99m Sulfur Colloid (SC) and glucoheptonate (GHP) surveillance of renal allografts (AG) on cyclosporin a (CSA) maintenance
The potential nephro-toxicity of CSA complicates the therapeutic management of AG with unexplained reduced function. Seven living related donor (LRD) and 23 cadaver (C) AG maintained, at least initially, on CSA and low dose prednisone and functioning for at least 2 months were studied during a 10 month period; mean serum creatinine (Scr) was 1.5 mg/dl for LRD and 2.35 mg/dl for C AG recipients. A total of 12 biopsies were performed in 10 recipients (2 LRD, 10 C AG) for unexplained SCr levels above 3.0 mg/dl. SC-GHP surveillance was carried out in each recipient between 4 and 15 times. SC exam was analyzed by temporal quantitation (as previously reported) and GHP exam was evaluated visually for AG perfusion, uptake and excretion of GHP. Biopsies were examined with H and E and immunofluorescent staining. Results were compared to therapeutic outcome, subsequent biopsy or AG nephrectomy. In summary, the comparison of SC-GHP exam and biopsy diagnosis in 12 instances for the differential diagnosis of CSA toxicity versus AR demonstrated correct assessment by the SC-GHP exam 12/12. AG biopsy diagnosis was correct in 8/12 instances.
- Research Organization:
- Section of Nuclear Medicine, Nephrology and Surgery, VA Medical Center
- OSTI ID:
- 5975161
- Report Number(s):
- CONF-850611-; TRN: 87-039249
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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550601* - Medicine- Unsealed Radionuclides in Diagnostics