Sulfur dioxide-induced chronic bronchitis in beagle dogs
This study was done to produce a model of chronic bronchitis. Twelve beagle dogs were exposed to 500 ppm sulfur dioxide (SO/sub 2/) for 2 h/d, 5d/wk for 21 wk and 4 dogs were sham-exposed to filtered ambient air for the same period. Exposure effects were evaluated by periodically examining the dogs using chest radiographs, pulmonary function, tracheal mucous clearance, and the cellular and soluble components of bronchopulmonary lavage fluids. Dogs were serially sacrificed after 13 and 21 wk of exposure and after 6 and 14 wk of recovery. Clinical signs produced in the SO/sub 2/-exposed dogs included mucoid nasal discharge, productive cough, moist rales on auscultation, tonsilitis, and conjunctivitis. Chest radiographs revealed mild peribronchiolar thickening. Histopathology, tracheal mucous clearance measurements, and lavage cytology were consistent with a diagnosis of chronic bronchitis. It is concluded that repeated exposure to 500 ppm SO/sub 2/ for 21 wk produced chronic bronchitis in the beagle dog. Complete recovery occurred within 5 wk following cessation of SO/sub 2/ exposure. 43 references, 2 figures, 2 tables.
- Research Organization:
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM
- DOE Contract Number:
- AC04-76EV01013
- OSTI ID:
- 5971266
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 13:4-6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BRONCHITIS
BIOLOGICAL MODELS
LUNGS
PATHOLOGICAL CHANGES
SULFUR DIOXIDE
TOXICITY
BEAGLES
BIOLOGICAL RECOVERY
BIOMEDICAL RADIOGRAPHY
DIAGNOSIS
DYNAMIC FUNCTION STUDIES
EXPERIMENTAL DATA
HISTOLOGY
SYMPTOMS
ANIMALS
BODY
CHALCOGENIDES
DATA
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
INFORMATION
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOLOGY
RECOVERY
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SULFUR COMPOUNDS
SULFUR OXIDES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)