Effect of chronic ethanol ingestion on the metabolism of copper, iron, manganese, selenium, and zinc in an animal model of alcoholic cardiomyopathy
Alcoholic cardiomyopathy (AC) is one of the diseases caused by alcohol abuse, and there has been considerable debate about the possibility that nutritional factors may be important in the etiology of AC. In addition, there is evidence that ethanol may affect the metabolism of trace elements. The purpose of this investigation was to determine if chronic ethanol administration produces changes in the metabolism of the essential metals copper, iron, manganese, zinc, and selenium using an animal model of AC. Eighteen male Sprague-Dawley rats were divided into three groups; an ad libitum control group (AL), a pair-fed control group (PF), and an ethanol-dosed group (ETOH). The latter group received gradually increasing concentrations (5-25%) of ethanol in the drinking water for 15 wk. Food intake was monitored and urine and feces collected for a 4-d period during the study to determine ethanol effects on trace-element balance. Growth of both the PF and ETOH animals was inhibited. Ethanol produced substantial increases in liver manganese and decreases in liver copper and zinc. Metal concentrations in heart and concentrations in other tissues studied (spleen, testes, brain, bone, kidney, and muscle) did not differ significantly among the groups, except for testes selenium and kidney zinc. Reduced food intake and ethanol ingestion were associated with a reduced percentage of ingested selenium excreted in the urine. Deficiencies of copper, iron, manganese, selenium, and zinc in myocardial tissue are not likely to be involved in the pathogenesis of AC in the rat. 38 references, 1 figure, 4 tables.
- Research Organization:
- Univ. of Medicine and Dentistry of New Jersey, Newark
- OSTI ID:
- 5968454
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 14:2-3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARDIOVASCULAR DISEASES
ETIOLOGY
COPPER
METABOLISM
ETHANOL
TOXICITY
IRON
MANGANESE
SELENIUM
ZINC
CHRONIC INTAKE
EXPERIMENTAL DATA
GROWTH
NUTRITION
NUTRITIONAL DEFICIENCY
RATS
VARIATIONS
ALCOHOLS
ANIMALS
DATA
DISEASES
ELEMENTS
HYDROXY COMPOUNDS
INFORMATION
INTAKE
MAMMALS
METALS
NUMERICAL DATA
ORGANIC COMPOUNDS
RODENTS
SEMIMETALS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)