Subnormal expression of cell-mediated and humoral immune responses in progeny disposed toward a high incidence of tumors after in utero exposure to benzo(a)pyrene
Pregnant mice were exposed to 150 ..mu..g benzol(a)pyrene (BaP) per gram of body weight during fetogenesis (d 11-17 of gestation) and the progeny were assayed for humoral and cell mediated immune responses at different time intervals after birth. Immature offspring (1-4 wk) were severely suppressed in their ability to produce antibody (plaque-) forming cells (PFC) against sheep red blood cells (SRBC) and in the ability of their lymphocytes to undergo a mixed lymphocyte response (MLR). Lymphocytes from these progeny showed a moderate to weak capacity to inhabit production of colony-forming units (CFU) in host spleens following transfer with semiallogeneic bone marrow (BM) cells into lethally x-irradiated recipients syngeneic to the BM (in vivo graft-versus-host response, GVHR). A severe and sustained suppression in the MLR and the PFC response occurred from the fifth month up to 18 mo. The in vivo GVHR, also subnormal later in life, was not as severely suppressed as the other two parameters. Tumor incidence in the BP-exposed progeny was 8- to 10-fold higher than in those encountering corn oil alone from 18 to 24 mo of age. These data show that in utero exposure to the chemical carcinogen BaP alters development of components needed for establishing competent hemoral and cell-mediated functions of the immune apparatus and leads to severe and sustained postnatal suppression of the defense mechanism. The immunodeficiency exhibited, particularly in the T-cell compartment (MLR, GVHR), before and during the increase in tumor frequency, may provide a favorable environment for the growth of nascent neoplasms induced by BaP. 30 references, 4 figures, 2 tables.
- Research Organization:
- Oak Ridge Associated Universities, TN
- DOE Contract Number:
- AC05-76OR00033
- OSTI ID:
- 5968443
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 14:4
- Country of Publication:
- United States
- Language:
- English
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BENZOPYRENE
CARCINOGENESIS
BONE MARROW CELLS
BIOLOGICAL RADIATION EFFECTS
FETUSES
SENSITIVITY
LYMPHOCYTES
IMMUNOSUPPRESSION
CFU
EXPERIMENTAL DATA
GRAFT-HOST REACTION
IMMUNE REACTIONS
LETHAL IRRADIATION
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BIOLOGICAL MATERIALS
BLOOD
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CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
DATA
DISEASES
HYDROCARBONS
INFORMATION
IRRADIATION
LEUKOCYTES
MAMMALS
MATERIALS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RADIATION EFFECTS
RODENTS
SOMATIC CELLS
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560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
560152 - Radiation Effects on Animals- Animals