Characterization of angiotensin II binding sites in African Green monkey uterus

Journal Article · Mon Jan 14 00:00:00 EST 1985 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(85)90097-9· OSTI ID:5965464

Petersen, E P; Wright, J W; Harding, J W

The observation that there are significant differences in the concentration, affinity, and specificity of both central nervous system (CNS) and peripheral angiotensin receptors among several different mammalian species, including the African Green monkey, led to the detailed analysis of /sup 125/I-angiotensin II binding in the uterus of the African Green monkey. The B/sub max/ for angiotensin receptors in uterine tissue from this species is 56.6 +/- 8.7 fmole per mg protein. The K/sub d/ for angiotensin II is .601 +/- .108 mM. The specificity of the receptor is similar to that reported for the uterus of the rat and dog. These results indicate that the angiotensin II receptors, although nearly absent from the CNS of the African Green monkey, are found in the uterus and are very similar to uterine receptors previously characterized in the rat and dog and support the use of these species as appropriate models for studying the biochemistry of angiotensin binding in the uterus. 25 references, 1 figure, 2 tables.

• Research Organization: Washington State Univ., Pullman
• OSTI ID: 5965464
• Journal Information: Life Sci.; (United States), Vol. 36:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANGIOTENSIN
CHEMICAL BONDS
RECEPTORS
AFFINITY
BIOCHEMISTRY
BIOLOGICAL MODELS
CENTRAL NERVOUS SYSTEM
EXPERIMENTAL DATA
IODINE 125
LABELLED COMPOUNDS
MONKEYS
TRACER TECHNIQUES
UTERUS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR AGENTS
CHEMISTRY
DATA
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FEMALE GENITALS
GLOBULINS
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NERVOUS SYSTEM
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROTEINS
RADIOISOTOPES
VASOCONSTRICTORS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques