Intragastric inulin as a measure of mucosal damage caused by aspirin
- Univ. of Minnesota-Duluth School of Medicine (USA)
In an attempt to find a method of gastric mucosal damage assessment that yields consistent results, the experiments presented here employed the measurement of the movement of inulin out of the gastric contents into the stomach wall and vascular compartment as an estimate of mucosal damage. Anesthetized male Sprague-Dawley rats were functionally nephrectomized and were administered a control or test solution containing 3H-inulin. The test solutions contained one of three doses of aspirin. Blood samples were taken at 15-min intervals over a 90-min exposure period. The stomach was removed from the animal and full-thickness tissue samples taken for measurement of 3H-inulin content. When the gastric mucosa was exposed to the test agents, there was a significantly greater accumulation of inulin in the body and antrum as well as in the plasma when compared to controls. We conclude that intragastric inulin can be employed to estimate gastric mucosal damage.
- OSTI ID:
- 5962501
- Journal Information:
- Journal of Pharmacological Methods; (USA), Vol. 24:3; ISSN 0160-5402
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ACETYLSALICYLIC ACID
BIOLOGICAL EFFECTS
INULIN
BIOSYNTHESIS
MUCOUS MEMBRANES
PATHOLOGICAL CHANGES
BIOLOGICAL INDICATORS
GASTROINTESTINAL TRACT
METABOLISM
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANALGESICS
ANIMALS
ANTIPYRETICS
CARBOHYDRATES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIGESTIVE SYSTEM
DRUGS
HYDROGEN COMPOUNDS
HYDROXY ACIDS
ISOTOPE APPLICATIONS
MAMMALS
MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
POLYSACCHARIDES
RODENTS
SACCHARIDES
SYNTHESIS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques