Platelet peripheral benzodiazepine receptors in repeated stress

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(91)90554-O· OSTI ID:5961885

Dar, D E; Bidder, M; Gavish, M ^[1]; Weizman, A; Karp, L; Tyano, S ^[2]; Grinshpoon, A; Bleich, A

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1. Technion-Israel Institute of Technology, Haifa (Israel)
2. Tel Aviv Univ. (Israel)

({sup 3}H)PK 11195 binding to platelet membranes and plasma stress hormones were studied in soldiers at the beginning of a parachute training course, following 6 days of preparatory exercises, and after the fourth actual parachute jump. A slight reduction (15%; NS) in the number of peripheral benzodiazepine receptors (PBR) was detected at the end of the exercise period, prior to the first jump. Reduced density of PBR was observed immediately after the repeated actual jumps. Equilibrium dissociation constants were not affected by the stressful situation. Plasma cortisol and prolactin levels remained unaltered during the entire study period.

• OSTI ID: 5961885
• Journal Information: Life Sciences; (USA), Vol. 48:4; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL STRESS
BIOLOGICAL EFFECTS
HYDROCORTISONE
BIOSYNTHESIS
LTH
SYMPATHOMIMETICS
RECEPTORS
BIOCHEMICAL REACTION KINETICS
BLOOD PLATELETS
CELL MEMBRANES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ADRENAL HORMONES
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CORTICOSTEROIDS
DRUGS
GLUCOCORTICOIDS
GONADOTROPINS
HORMONES
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KETONES
KINETICS
MATERIALS
MEMBRANE PROTEINS
MEMBRANES
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PITUITARY HORMONES
PREGNANES
PROTEINS
REACTION KINETICS
STEROIDS
SYNTHESIS
550201* - Biochemistry- Tracer Techniques