Prevention of HLA alloimmunization: Role of leukocyte depletion and UV-B irradiation

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · Yale Journal of Biology and Medicine; (USA)

OSTI ID:5956523

Snyder, E L ^[1]

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1. Yale Univ. School of Medicine, New Haven, CT (USA)

HLA alloimmunization is a major cause of the platelet refractory state. The stimulus for HLA alloimmunization is believed to derive from incompatibility between the recipient's lymphocytes and the passenger donor lymphocytes contained in transfused red cells or platelet concentrates. Two techniques to prevent post-transfusion HLA alloimmunization include filtration, which physically removes the donor lymphocytes, and UV-B irradiation, which renders the donor leukocytes biologically inactive. The role of these two techniques in the prevention of HLA alloimmunization is the focus of this review.42 references.

• OSTI ID: 5956523
• Journal Information: Yale Journal of Biology and Medicine; (USA), Vol. 63:5; ISSN 0044-0086
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLOOD PLATELETS
TRANSFUSIONS
LEUKOCYTES
BIOLOGICAL RADIATION EFFECTS
ANTIGEN-ANTIBODY REACTIONS
ANTIGENS
DOGS
LYMPHOCYTES
MAN
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ANIMALS
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BLOOD CELLS
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ELECTROMAGNETIC RADIATION
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PRIMATES
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
THERAPY
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560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture