In vitro and in vivo studies on potentiation of cytotoxic effects of anticancer drugs or cobalt 60 gamma ray by interferon on human neoplastic cells
A possibility that interferon may potentiate the cytotoxic effects of anticancer drugs or /sup 60/Co gamma ray on human neoplastic cells was studied by in vitro and in vivo experimental procedures. The human neoplastic cells used were HeLa (uterine cervical cancer) and WI-38 CT-1 (embryonic lung fibroblasts transformed in culture by /sup 60/Co gamma ray) cells. As normal human cells, WI-38 cells were used. Interferon was a preparation of beta-type produced by human fibroblasts. The cytotoxicity was determined by colony formation for in vitro experiments and by tumor growth for animal experiments. Of 17 anticancer drugs, the cytotoxic effects of six drugs, namely, peplomycin, bleomycin, aclacinomycin, cisplatin, 5-fluorouracil (5-FU), and Adriamycin (doxorubicin) were potentiated by concomitant application of interferon. The cytolethal effects of /sup 60/Co gamma ray were also enhanced by interferon. The growth of tumor induced by transplantation of HeLa cells into a nude mouse was remarkably reduced by combination therapy of interferon and 5-FU. The current results indicate a possibility that combined therapy of certain types of anticancer drugs or /sup 60/Co gamma ray with interferon may be effective in treatment of cancer patients.
- Research Organization:
- Kawasaki Medical School, Japan
- OSTI ID:
- 5948836
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 54:10
- Country of Publication:
- United States
- Language:
- English
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ANTINEOPLASTIC DRUGS
TESTING
INTERFERON
RADIOSENSITIVITY EFFECTS
NEOPLASMS
CHEMOTHERAPY
GROWTH
RADIOTHERAPY
COBALT 60
FIBROBLASTS
GAMMA RADIATION
HELA CELLS
IN VITRO
IN VIVO
MAN
MICE
PATIENTS
SYNERGISM
TRANSPLANTS
ANIMAL CELLS
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BETA-MINUS DECAY RADIOISOTOPES
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
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ELECTROMAGNETIC RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
PRIMATES
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RODENTS
SOMATIC CELLS
THERAPY
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550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine