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Title: Hormonal monitoring of early pregnancy by a direct radioimmunoassay of steroid glucuronides in first morning urine

The usefulness of the direct 4-hour radioimmunoassay of estriol-16-glucuronide (E/sub 3/G) and pregnanediol-3-glucuronide (P/sub 2/G) in first morning urine (FMU) for establishing a prognosis of the early pregnancy outcome was evaluated in 106 patients that became pregnant. Microaliquots of FMU were serially assayed from day 3 of the conception cycle until day 80 of pregnancy. The E/sub 3/G and P/sub 2/G profiles of 19 pregnancies which terminated in spontaneous abortion with either a diagnosis of the blighted ovum syndrome (n = 11) or presumption of a corpus luteum/trophoblast failure (n = 8) have been compared with those of clinically normal pregnancies (n = 87). Normal pregnancies displayed typical patterns of E/sub 3/G and P/sub 2/G development, while variations were observed in abortive events that reflected changes of the fetoplacental unit.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
5943309
Resource Type:
Journal Article
Resource Relation:
Journal Name: Fert. Steril.; (United States); Journal Volume: 42:5
Research Org:
Centro de Educacion Medica e Investigaciones Clinicas, Buenos Aires, Argentina
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; ESTRIOL; RADIOIMMUNOASSAY; PREGNANCY; DIAGNOSIS; PREGNANEDIOL; REPRODUCTIVE DISORDERS; ABORTION; PATIENTS; ESTRANES; ESTROGENS; HORMONES; HYDROXY COMPOUNDS; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; ORGANIC COMPOUNDS; PREGNANES; RADIOASSAY; RADIOIMMUNOLOGY; STEROID HORMONES; STEROIDS; TRACER TECHNIQUES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics; 550901 -- Pathology-- Tracer Techniques