Hematological responses to arsine exposure: quantitation of exposure response in mice
Hematological responses of the of mice to arsine exposures for 1 hr at 5 to 26 part per million volume (ppmv) are described. Exposure concentrations ranged from a no-effect level for the endpoints studied (5 ppmv) to a concentration lethal to all mice in 4 days (26 ppmv). Hematocrit values at 24 hr after exposure decreased linearly with increasing arsine concentration in the range 5 to 26 ppmv; the hematocrits of the 26-ppmv group reached 10.5% at 24 hr, compared to 48.4% for control mice. Hematocritis of mice from all surviving groups were at or slightly above control values by 11 days after exposure. Changes in numbers of erythrocytes paralleled changes in hematocrit. Significant increases in circulating reticulocytes occurred at 1 and 5 days after exposure ; reticulocyte values returned to control levels by 11 days after exposure. Changes in erythrocyte osmotic fragility were observed in mice exposed to 15 and 26 ppmv arsine. 22 references, 3 figures, 3 tables.
- Research Organization:
- Argonne National Lab., IL
- DOE Contract Number:
- W-31-109-ENG-38
- OSTI ID:
- 5941002
- Journal Information:
- Fundam. Appl. Toxicol.; (United States), Vol. 5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ARSENIC
TOXICITY
ERYTHROCYTES
HEMOLYSIS
BLOOD COUNT
DOSE-RESPONSE RELATIONSHIPS
ECOLOGICAL CONCENTRATION
EXPERIMENTAL DATA
MICE
OSMOSIS
RETICULOCYTES
SURVIVAL TIME
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DATA
DIFFUSION
ELEMENTS
INFORMATION
LYSIS
MAMMALS
MATERIALS
NUMERICAL DATA
PATHOLOGICAL CHANGES
RODENTS
SEMIMETALS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)