Inhibitory effects of xylitol on gastric emptying and food intake
The authors have previously shown, using a 99m-Tc scrambled egg meal, that pentose sugars (i.e. xylose and arabinose) markedly prolong gastric emptying. Others have reported that slowing of gastric emptying may decrease appetite and thus decrease food intake. In the present study, the authors utilized the effects of xylitol (an FDA-approved pentose sugar) on gastric emptying to study the correlation between gastric emptying and food intake. Initially, gastric emptying was measured in human volunteers utilizing a standardized 99m-Tc-scrambled egg meal washed with 50 cc tap water. Results demonstrated a significant reduction in food intake (892 +- 65 kcal with water vs 654 +- 26 kcal following the ingestion of 25 gm xylitol (p<0.05). We conclude that the effect of pentose sugars in prolonging gastric emptying directly influences food intake and contributes to early satiety. The data suggest a role of xylitol as an essentially non-caloric food additive potentially important in diet control.
- Research Organization:
- V.A. Medical Center, Minneapolis, MN
- OSTI ID:
- 5938515
- Report Number(s):
- CONF-850611-; TRN: 87-039304
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
DIGESTION
INHIBITION
STOMACH
DYNAMIC FUNCTION STUDIES
XYLOSE
BIOLOGICAL EFFECTS
DIAGNOSTIC USES
ARABINOSE
DIET
INGESTION
ORAL ADMINISTRATION
PENTOSES
SCINTISCANNING
TECHNETIUM 99
WATER
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MONOSACCHARIDES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SACCHARIDES
TECHNETIUM ISOTOPES
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques