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Title: Evaluation of the effects of methanol during early pregnancy in the rat

Recent attention to methanol (MeOH) as a potential alternative fuel prompted an evaluation of the chemical's effects during very early pregnancy. Rats were dosed by gavage during Days 1-8 of pregnancy at 0, 1.6, 2.4 or 3.2 g MeOH/kg/day. Groups of animals were killed on Days 9, 11 or 20 of pregnancy, and maternal, embryonic, or fetal parameters were assessed, depending on the stage of pregnancy. The decidual cell response (DCR) technique was also applied to rats treated with MeOH during pseudopregnancy. (Copyright (c) 1993 Elsevier Scientific Publishers Ireland Ltd.).
Authors:
Publication Date:
OSTI Identifier:
5937240
Report Number(s):
PB-93-231850/XAB; EPA--600/J-93/377
Resource Type:
Technical Report
Resource Relation:
Other Information: Pub. in Toxicology 79, 205-214(May 1993)
Research Org:
Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 09 BIOMASS FUELS; METHANOL; HEALTH HAZARDS; TERATOGEN SCREENING; RATS; PREGNANCY; EXPERIMENTAL DATA; FUEL SUBSTITUTION; ALCOHOLS; ANIMALS; DATA; HAZARDS; HYDROXY COMPOUNDS; INFORMATION; MAMMALS; NUMERICAL DATA; ORGANIC COMPOUNDS; RODENTS; SCREENING; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology; 096000 -- Biomass Fuels-- Health & Safety-- (1990-)