Marfan syndrome is closely linked to a marker on chromosome 15q1. 5 r arrow q2. 1

Journal Article · Wed May 15 00:00:00 EDT 1991 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.88.10.4486· OSTI ID:5933916

Tsipouras, P; Sarfarazi, M; Devi, A ^[1]; Weiffenbach, B ^[2]; Boxer, M ^[3]

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1. Univ. of Connecticut Health Center, Farmington (United States)
2. Collaborative Research, Inc., Waltham, MA (United States)
3. Ninewells Hospital and Medical School, Dundee (Scotland)

Marfan syndrome is a systemic disorder of the connective tissue inherited as an autosomal dominant trait. The disorder imparts significant morbidity and martality. The etiology of the disorder remains elusive. A recent study localized the gene for Marfan syndrome on chromosome 15. The authors present data showing that marker D15S48 is genetically linked to Marfan syndrome. Pairwise linkage analysis gave a maximum lod (logarithm of odds) score of Z = 11.78 at {theta} = 0.02. Furthermore our data suggest that the Marfan syndrome locus is possibly flanked on either side by D15S48 and D15S49.

• OSTI ID: 5933916
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Vol. 88:10; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HEREDITARY DISEASES
ETIOLOGY
HETEROCHROMOSOMES
GENETIC MAPPING
DOMINANT MUTATIONS
MAN
MORTALITY
PHENOTYPE
RFLPS
ANIMALS
CHROMOSOMES
DISEASES
MAMMALS
MAPPING
MUTATIONS
PRIMATES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques