Chemical induction of tumors in oysters by a mixture of aromatic and chlorinated hydrocarbons, amines and metals
Tumors were induced in eastern oysters (Crassostrea virginica) by a mixture of aromatic hydrocarbons, an aromatic amine, polychlorinated biphenyls, chlorinated hydrocarbons, a nitrosoamine and heavy metals. Kidney and enteric tumors developed in oysters following exposure to a mixture containing 3,4-benzopyrene, 1,2-benzanthracene, 2-aminofluorene, N-nitrosodiethylamine, technical chlordane, Aroclors 1242 and 1254, p,p'-DDE, cadmium (CdCl2), chromium (K2CrO4) and lead (Pb(NO3)2). 2-Aminofluorene and N-nitrosodiethylamine, not measured in Black Rock Harbor sediment, were both added at 0.6 and 6.0 micrograms/g dry sediment. A 3% prevalence of low-grade renal and gastrointestinal tumors developed after 30 days in oysters fed water-column suspended sediment particulate spiked with the mixture of chemicals. Disease progression was most advanced in enteric adenomas. Both types are comparable to those produced after 30 days in the same organs by chemically contaminated Black Rock Harbor sediment.
- Research Organization:
- Environmental Protection Agency, Narragansett, RI (United States). Environmental Research Lab.
- OSTI ID:
- 5922591
- Report Number(s):
- PB-93-229326/XAB; EPA-600/J-93/310
- Resource Relation:
- Other Information: Pub. in Marine Environmental Research 34, 59-63(1992)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
CHEMICAL EFFLUENTS
BIOLOGICAL EFFECTS
OYSTERS
NEOPLASMS
ADENOMAS
AMINES
ANIMALS
AROMATICS
BENZANTHRACENE
BENZOPYRENE
CADMIUM
CARCINOGENS
CHLORINATED AROMATIC HYDROCARBONS
CHROMIUM
CONTAMINATION
METALS
ORGANS
PESTICIDES
POLLUTANTS
POLYCHLORINATED BIPHENYLS
SEDIMENTS
TRACE AMOUNTS
WATER POLLUTION
AQUATIC ORGANISMS
BODY
CARCINOMAS
CHEMICAL WASTES
CONDENSED AROMATICS
DISEASES
ELEMENTS
HALOGENATED AROMATIC HYDROCARBONS
HYDROCARBONS
INVERTEBRATES
MOLLUSCS
NONRADIOACTIVE WASTES
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
POLLUTION
TRANSITION ELEMENTS
WASTES
560300* - Chemicals Metabolism & Toxicology
540350 - Environment
Aquatic- Site Resource & Use Studies- (1990-)