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Title: Abnormal epidermal changes after argon laser treatment

A 26-year-old woman with a congenital port-wine stain on the forehead was treated three times at 2-month intervals with an argon laser. Six months after the last treatment, moderate blanching and mild scaling confined to the treated area was observed. A biopsy specimen of the treated area revealed a significant decrease in ectatic vessels. However, epidermal changes similar to those of actinic keratosis with disorganized cell layers and marked cytologic abnormalities were seen. Analysis of peripheral blood lymphocytes for a defect in DNA repair was negative. Multiple, argon laser-induced photothermal effects may be responsible for the changes observed in our case and may lead to premalignant epidermal transformation.
Authors:
; ; ; ; ;  [1]
  1. (Univ. of Vienna (Austria))
Publication Date:
OSTI Identifier:
5921830
Resource Type:
Journal Article
Resource Relation:
Journal Name: Journal of the American Academy of Dermatology; (USA); Journal Volume: 24:2 Pt 2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EPIDERMIS; MORPHOLOGICAL CHANGES; LASER RADIATION; BIOLOGICAL EFFECTS; BIOPSY; DNA REPAIR; GAS LASERS; LYMPHOCYTES; ANIMAL CELLS; ANIMAL TISSUES; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DIAGNOSTIC TECHNIQUES; ELECTROMAGNETIC RADIATION; EPITHELIUM; LASERS; LEUKOCYTES; MATERIALS; ORGANS; RADIATIONS; RECOVERY; REPAIR; SKIN; SOMATIC CELLS; TISSUES 560400* -- Other Environmental Pollutant Effects