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Title: Reduction of radiation-induced cell cycle blocks by caffeine does not necessarily lead to increased cell killing

Abstract

The effect of caffeine upon the radiosensitivities of three human tumor lines was examined and correlated with its action upon the radiation-induced S-phase and G2-phase blocks. Caffeine was found to reduce at least partially the S-phase and G2-phase blocks in all the cell lines examined but potentiated cytotoxicity in only one of the three tumor lines. That reductions have been demonstrated to occur in the absence of increased cell killing provides supporting evidence for the hypothesis that reductions may not be causal in those cases when potentiation of radiation-induced cytotoxicity is observed in the presence of caffeine.

Authors:
 [1]
  1. Institute of Cancer Research, Sutton, Surrey (England)
Publication Date:
OSTI Identifier:
5917016
Resource Type:
Journal Article
Journal Name:
Radiation Research; (USA)
Additional Journal Information:
Journal Volume: 125:3; Journal ID: ISSN 0033-7587
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CAFFEINE; RADIOSENSITIVITY EFFECTS; TUMOR CELLS; RADIOSENSITIVITY; CELL CYCLE; CELL KILLING; COBALT ISOTOPES; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; IN VITRO; MAN; ANALEPTICS; ANIMAL CELLS; ANIMALS; AROMATICS; AZAARENES; CENTRAL NERVOUS SYSTEM AGENTS; DRUGS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; IONIZING RADIATIONS; ISOTOPES; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PRIMATES; PURINES; RADIATIONS; VERTEBRATES; XANTHINES; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture

Citation Formats

Musk, S R. Reduction of radiation-induced cell cycle blocks by caffeine does not necessarily lead to increased cell killing. United States: N. p., 1991. Web. doi:10.2307/3578108.
Musk, S R. Reduction of radiation-induced cell cycle blocks by caffeine does not necessarily lead to increased cell killing. United States. https://doi.org/10.2307/3578108
Musk, S R. 1991. "Reduction of radiation-induced cell cycle blocks by caffeine does not necessarily lead to increased cell killing". United States. https://doi.org/10.2307/3578108.
@article{osti_5917016,
title = {Reduction of radiation-induced cell cycle blocks by caffeine does not necessarily lead to increased cell killing},
author = {Musk, S R},
abstractNote = {The effect of caffeine upon the radiosensitivities of three human tumor lines was examined and correlated with its action upon the radiation-induced S-phase and G2-phase blocks. Caffeine was found to reduce at least partially the S-phase and G2-phase blocks in all the cell lines examined but potentiated cytotoxicity in only one of the three tumor lines. That reductions have been demonstrated to occur in the absence of increased cell killing provides supporting evidence for the hypothesis that reductions may not be causal in those cases when potentiation of radiation-induced cytotoxicity is observed in the presence of caffeine.},
doi = {10.2307/3578108},
url = {https://www.osti.gov/biblio/5917016}, journal = {Radiation Research; (USA)},
issn = {0033-7587},
number = ,
volume = 125:3,
place = {United States},
year = {Fri Mar 01 00:00:00 EST 1991},
month = {Fri Mar 01 00:00:00 EST 1991}
}