Effects of ethanol on cAMP production in murine embryonic palate mesenchymal cells

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(91)90065-J· OSTI ID:5904821

Weston, W M; Greene, R M ^[1]

---

1. Thomas Jefferson Univ., Philadelphia, PA (United States)

Ethanol affected the ability of murine embryonic palate mesenchymal (MEPM) cells to produce cAMP in response to hormone treatment. Acute exposure to ethanol resulted in an increase in hormone-stimulated cAMP levels, while chronic ethanol treatment led to decreased sensitivity to hormone. Forskolin-stimulated cAMP levels were decreased by both acute and chronic ethanol treatment, while the cells' response to cholera toxin was unchanged by ethanol treatment. The lack of sensitivity of the cholera toxin response to ethanol suggests that,in contrast to what has been observed in other systems, ethanol does not affect the production or activity of G{alpha}s in MEPM cells. These results suggest a possible explanation for the molecular basis for the craniofacial abnormalities observed in the fetal alcohol syndrome.

• OSTI ID: 5904821
• Journal Information: Life Sciences; (United States), Vol. 49:7; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMP
BIOSYNTHESIS
ETHANOL
BIOLOGICAL EFFECTS
ANIMAL CELLS
BRAIN
CONGENITAL MALFORMATIONS
EMBRYOS
MICE
ALCOHOLS
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
HYDROXY COMPOUNDS
MALFORMATIONS
MAMMALS
NERVOUS SYSTEM
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RODENTS
SYNTHESIS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology