Mapping the x-linked lymphoproliferative syndrome

Journal Article · Wed Apr 01 00:00:00 EST 1987 · Proc. Natl. Acad. Sci. U.S.A.; (United States)

DOI:https://doi.org/10.1073/pnas.84.7.2015· OSTI ID:5903361

Skare, J C; Milunsky, A; Byron, K S; Sullivan, J L

The X-linked lymphoproliferative syndrome is triggered by Epstein-Barr virus infection and results in fatal mononucleosis, immunodeficiency, and lymphoproliferative disorders. This study shows that the mutation responsible for X-linked lymphoproliferative syndrome is genetically linked to a restriction fragment length polymorphism detected with the DXS42 probe (from Xq24-q27). The most likely recombination frequency between the loci is 4%, and the associated logarithm of the odds is 5.26. Haplotype analysis using flanking restriction fragment length polymorphism markers indicates that the locus for X-linked lymphoproliferative syndrome is distal to probe DXS42 but proximal to probe DXS99 (from Xq26-q27). It is now possible to predict which members of a family with X-linked lymphoproliferative syndrome are carrier females and to diagnose the syndrome prenatally.

• Research Organization: Boston Univ. School of Medicine, MA
• OSTI ID: 5903361
• Journal Information: Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 84:7
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
DNA
AUTORADIOGRAPHY
HEREDITARY DISEASES
GENETICS
X CHROMOSOME
GENETIC MAPPING
LYMPHOCYTES
MUTATIONS
PATIENTS
VIRAL DISEASES
VIRUSES
ANIMAL CELLS
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMES
CONNECTIVE TISSUE CELLS
DISEASES
HETEROCHROMOSOMES
INFECTIOUS DISEASES
LEUKOCYTES
MAPPING
MATERIALS
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PARASITES
SOMATIC CELLS
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