Spinal cord blood flow measured by /sup 14/C-iodoantipyrine autoradiography during and after graded spinal cord compression in rats

Journal Article · Mon May 01 00:00:00 EDT 1989 · Surg. Neurol. (Tryon, N.C.); (United States)

OSTI ID:5902541

Holtz, A; Nystroem, B G; Gerdin, B

The relations between degree of thoracic spinal cord compression causing myelographic block, reversible paraparesis, and extinction of the sensory evoked potential on one hand, and spinal cord blood flow on the other, were investigated. This was done in rats using the blocking weight-technique and /sup 14/C-iodoantipyrine autoradiography. A load of 9 g caused myelographic block. Five minutes of compression with that load caused a reduction of spinal cord blood flow to about 25%, but 5 and 60 minutes after the compression spinal cord blood flow was restored to 60% of the pretrauma value. A load of 35 g for 5 minutes caused transient paraparesis. Recovery to about 30% was observed 5 and 60 minutes thereafter. During compression at a load of 55 g, which caused almost total extinction of sensory evoked potential and irreversible paraplegia, spinal cord blood flow under the load ceased. The results indicate that myelographic block occurs at a load which does not cause irreversible paraparesis and that a load which permits sensory evoked potential to be elicited results in potentially salvageable damage.

• Research Organization: University Hospital, Uppsala (Sweden)
• OSTI ID: 5902541
• Journal Information: Surg. Neurol. (Tryon, N.C.); (United States), Vol. 31:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
SPINAL CORD
BLOOD FLOW
ANTIPYRINE
AUTORADIOGRAPHY
BLOOD PRESSURE
CARBON 14 COMPOUNDS
RATS
ANIMALS
ANTIPYRETICS
AZOLES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
HETEROCYCLIC COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRAZOLES
PYRAZOLINES
RODENTS
VERTEBRATES
550901* - Pathology- Tracer Techniques