Myelostimulatory activity of recombinant human interleukin-2 in mice

Journal Article · Mon May 01 00:00:00 EDT 1989 · Blood; (United States)

OSTI ID:5901456

Talmadge, J E; Schneider, M; Keller, J; Ruscetti, F; Longo, D; Pennington, R; Bowersox, O; Tribble, H

In a series of studies designed to extend our understanding of interleukin-2 (IL-2) and to study the effect of biologic response modifiers on bone marrow, we observed that administering recombinant human (rH) IL-2 to normal mice resulted in an increase in the frequency of colony-forming units-culture (CFU-C) in bone marrow. In addition, rH IL-2 was able to accelerate host recovery from cyclophosphamide (CTX)- or radiation-induced bone marrow depression and peripheral blood leukopenia. Not only can rH IL-2 accelerate, in a dose-dependent manner, the return of bone marrow, peripheral blood cellularity, and CFU-C frequency to normal levels following cytoreduction by CTX or irradiation, but it also significantly increases CFU-C frequency to greater than normal levels. Furthermore, rH IL-2 can significantly prolong survival of animals receiving a lethal dose of irradiation or CTX. Thus, multiple mechanisms are responsible for the synergistic therapeutic activity associated with rH IL-2 and CTX. rH IL-2 does not act only as an immunomodulatory agent in the presence or absence of suppressor T cells, but also accelerates host recovery from cytoreductive agents, resulting in decreased leukopenia and perhaps resistances to secondary infection. Thus, rH IL-2 plus chemotherapy may increase therapeutic activity against neoplastic disease, not only by adding immune stimulation to the direct antitumor effect of the drug but also by allowing delivery of higher, more effective doses of chemotherapy.

• OSTI ID: 5901456
• Journal Information: Blood; (United States), Vol. 73:6
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW CELLS
COLONY FORMATION
LYMPHOKINES
RADIOSENSITIVITY EFFECTS
BIOLOGICAL RECOVERY
DOSE-RESPONSE RELATIONSHIPS
ENDOXAN
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STEM CELLS
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ANIMAL CELLS
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BLOOD
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BODY FLUIDS
CONNECTIVE TISSUE CELLS
DRUGS
ELECTROMAGNETIC RADIATION
GROWTH FACTORS
IMMUNOSUPPRESSIVE DRUGS
IONIZING RADIATIONS
LEUKOCYTES
MAMMALS
MATERIALS
MITOGENS
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RADIATIONS
RECOVERY
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560152* - Radiation Effects on Animals- Animals