Correlation among lung damage after radiation, amount of lipid peroxides, and antioxidant enzyme activities
The correlation between lipid peroxidation and morphologic changes was examined in Sprague-Dawley rat lungs after 30 Gy single thoracic radiation. The rats were sacrificed every week until the end of the fifth week after radiation. The left lungs were used for the measurement of lipid peroxides and antioxidant enzymes activities. The right lungs were examined by light and electron microscopy. Amounts of lung lipid peroxides were within normal limits, and no cellular degenerative changes were observed in the lungs except for subendothelial and interstitial edema 2 weeks after radiation. Lipid peroxides drastically increased and marked degenerative cellular changes such as edematous swelling, vacuolation, and destruction of cell membranes occurred in the alveolar septa following the third week after radiation. The activities of catalase were significantly higher during the period from the second to the fifth week and those of superoxide dismutase and glutathione peroxidase increased at the end of the fifth week. Our results demonstrated that the acceleration of lipid peroxidation was well correlated with the morphologic expression of cell injury in the irradiated lungs.
- Research Organization:
- Univ. of Tsukuba, Ibarakiken (Japan)
- OSTI ID:
- 5901306
- Journal Information:
- Exp. Mol. Pathol.; (United States), Vol. 50:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CATALASE
ENZYME ACTIVITY
LIPIDS
METABOLISM
LUNGS
BIOLOGICAL RADIATION EFFECTS
PEROXIDASES
SUPEROXIDE DISMUTASE
ANTIOXIDANTS
CELL MEMBRANES
ELECTRON MICROSCOPY
MORPHOLOGICAL CHANGES
RATS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
ENZYMES
MAMMALS
MEMBRANES
MICROSCOPY
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
RADIATION EFFECTS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals