Endotoxin of Escherichia coli and permeability of the mammary glands of goats
Serial collections of milk were used to determine where in the mammary gland endotoxin of Escherichia coli was effective in altering the transfer of selected milk components into blood and blood components into milk. Lactating goats had half the gland infused with 1 ..mu..g of endotoxin and the other half served as a control. Sodium-24 and /sup 42/K or (/sup 14/C) lactose were included with /sup 141/Ce in the infusate in some experiments, whereas in others /sup 99m/Tc-labelled albumin or /sup 24/Na and /sup 42/K were given intravenously 2 h after the endotoxin infusion. Milk was collected 3 h after endotoxin infusion. Endotoxin increased the loss of /sup 24/Na, /sup 42/K, and (/sup 14/C) lactose from the mammary gland and increased the transfer of /sup 24/Na and /sup 99m/Tc-albumin into the gland. The transfer in of /sup 42/K was reduced compared with control halves. Movement of stable Na and K was in accord with the movement of the /sup 24/Na and /sup 42/K. Endotoxin was effective in all parts of the gland but particularly from the mid-portion upward to the alveoli. For the control halves there was evidence that some /sup 24/Na and /sup 42/K crossed the ductal or cisternal epithelium into blood outside of the alveoli, whereas only /sup 42/K provided evidence for transfer from blood to milk in these same regions. There was no demonstrable transfer of lactose and albumin in regions other than the alveoli.
- Research Organization:
- New York State College of Veterinary Medicine, Ithaca
- OSTI ID:
- 5900112
- Journal Information:
- J. Dairy Sci.; (United States), Vol. 70:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ENDOTOXINS
BIOLOGICAL EFFECTS
ESCHERICHIA COLI
GOATS
MAMMARY GLANDS
PERMEABILITY
ALBUMINS
CARBON 14
CERIUM 141
LACTOSE
POTASSIUM 42
SODIUM 24
TECHNETIUM 99
TRACER TECHNIQUES
ALKALI METAL ISOTOPES
ANIMALS
ANTIGENS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARBON ISOTOPES
CERIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DISACCHARIDES
DOMESTIC ANIMALS
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MATERIALS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
POTASSIUM ISOTOPES
PROTEINS
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RUMINANTS
SACCHARIDES
SECONDS LIVING RADIOISOTOPES
SODIUM ISOTOPES
TECHNETIUM ISOTOPES
TOXIC MATERIALS
TOXINS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
553005* - Agriculture & Food Technology- Animal Husbandry- (1987-)