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Title: Effects of alcohol feeding on androgen receptors in the rat pituitary gland

Abstract

Specific binding of testosterone-1..beta..,2..beta..-/sup 3/H by cytosol from anterior pituitary gland of ethanol-fed, isocaloric control, and castrated control and ethanol-fed rats with or without testosterone treatment has been investigated by charcoal assay. The number of androgen binding sites was significantly reduced in alcohol-fed rats when compared to the isocaloric control value, with no significant change in Kd. Castration significantly increased the number of receptor sites in control rats and when castrated control animals were treated with testosterone the binding sites were decreased to the intact control level. In contrast, castration or testosterone given to castrated alcohol-fed rats did not alter alcohol-induced reduction of the receptor sites. The binding affinity (Kd) is identical in all groups. The concentration of serum luteinizing hormone (LH) was significantly lower in alcohol-fed rats when compared to that of normal controls. An increased serum LH level with a decreased testosterone level was noted in castrated control rats. However, castration of alcohol-fed rats had little or no effects on the concentrations of LH and testosterone. Administration of testosterone suppressed castration-induced high LH in control rats but alcohol induced reduction of LH level was not altered by this treatment. These findings indicate that alcohol exerts a suppressive effectmore » on the content of androgen receptors and secretory functions of gonadotropins in the pituitary gland. 23 references, 1 figure, 1 table.« less

Authors:
Publication Date:
Research Org.:
Univ. of Oklahoma Health Sciences Center, Oklahoma City
OSTI Identifier:
5898642
Resource Type:
Journal Article
Journal Name:
Life Sci.; (United States)
Additional Journal Information:
Journal Volume: 41:17
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; ETHANOL; BIOLOGICAL EFFECTS; LH; BIOSYNTHESIS; TESTOSTERONE; BIOCHEMICAL REACTION KINETICS; RECEPTORS; INHIBITION; PITUITARY GLAND; RATS; TRACER TECHNIQUES; TRITIUM COMPOUNDS; ALCOHOLS; ANDROGENS; ANDROSTANES; ANIMALS; BODY; ENDOCRINE GLANDS; GLANDS; GONADOTROPINS; HORMONES; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; KETONES; KINETICS; LABELLED COMPOUNDS; MAMMALS; MEMBRANE PROTEINS; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; PITUITARY HORMONES; PROTEINS; REACTION KINETICS; RODENTS; STEROID HORMONES; STEROIDS; SYNTHESIS; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology; 550201 - Biochemistry- Tracer Techniques

Citation Formats

Chung, K W. Effects of alcohol feeding on androgen receptors in the rat pituitary gland. United States: N. p., 1987. Web. doi:10.1016/0024-3205(87)90483-8.
Chung, K W. Effects of alcohol feeding on androgen receptors in the rat pituitary gland. United States. https://doi.org/10.1016/0024-3205(87)90483-8
Chung, K W. 1987. "Effects of alcohol feeding on androgen receptors in the rat pituitary gland". United States. https://doi.org/10.1016/0024-3205(87)90483-8.
@article{osti_5898642,
title = {Effects of alcohol feeding on androgen receptors in the rat pituitary gland},
author = {Chung, K W},
abstractNote = {Specific binding of testosterone-1..beta..,2..beta..-/sup 3/H by cytosol from anterior pituitary gland of ethanol-fed, isocaloric control, and castrated control and ethanol-fed rats with or without testosterone treatment has been investigated by charcoal assay. The number of androgen binding sites was significantly reduced in alcohol-fed rats when compared to the isocaloric control value, with no significant change in Kd. Castration significantly increased the number of receptor sites in control rats and when castrated control animals were treated with testosterone the binding sites were decreased to the intact control level. In contrast, castration or testosterone given to castrated alcohol-fed rats did not alter alcohol-induced reduction of the receptor sites. The binding affinity (Kd) is identical in all groups. The concentration of serum luteinizing hormone (LH) was significantly lower in alcohol-fed rats when compared to that of normal controls. An increased serum LH level with a decreased testosterone level was noted in castrated control rats. However, castration of alcohol-fed rats had little or no effects on the concentrations of LH and testosterone. Administration of testosterone suppressed castration-induced high LH in control rats but alcohol induced reduction of LH level was not altered by this treatment. These findings indicate that alcohol exerts a suppressive effect on the content of androgen receptors and secretory functions of gonadotropins in the pituitary gland. 23 references, 1 figure, 1 table.},
doi = {10.1016/0024-3205(87)90483-8},
url = {https://www.osti.gov/biblio/5898642}, journal = {Life Sci.; (United States)},
number = ,
volume = 41:17,
place = {United States},
year = {Mon Oct 26 00:00:00 EST 1987},
month = {Mon Oct 26 00:00:00 EST 1987}
}