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Title: Effect of LET and microdistribution of radiation on the transformation in vitro and in vivo. Comprehensive progress report

Work has involved the following three areas: (1) an investigation of the mechanisms of radiation carcinogenesis by studying the events involved in the process of malignant transformation of mouse 10 T-1/2 cells; (2) an investigation of the effects of promoting agents on radiation-induced transformation in vitro; and (3) an investigation of the induction of transformation by internally emitting radionuclides incorporated into cellular DNA. The latter area has been extended to include studies of mutagenesis by these radionuclides in human lymphoblasts, and molecular measurements of DNA strand breaks. During the past year, research has focused on the first area, as well as on studies of the mutagenic effects of incorporated radionuclides.
Authors:
Publication Date:
OSTI Identifier:
5895948
Report Number(s):
DOE/EV/04322-T2
ON: DE83017429
DOE Contract Number:
AC02-77EV04322
Resource Type:
Technical Report
Research Org:
Harvard Univ., Boston, MA (USA). School of Public Health
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANIMAL CELLS; ONCOGENIC TRANSFORMATIONS; CARCINOGENESIS; RADIOINDUCTION; TUMOR PROMOTERS; RADIOSENSITIVITY EFFECTS; BIOLOGICAL EFFECTS; CELL CULTURES; IN VITRO; INTERNAL IRRADIATION; IODINE 125; MICE; MUTAGENESIS; STRAND BREAKS; ANIMALS; BETA DECAY RADIOISOTOPES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; IRRADIATION; ISOTOPES; MAMMALS; NUCLEI; ODD-EVEN NUCLEI; PATHOGENESIS; PROMOTERS; RADIOISOTOPES; RODENTS; VERTEBRATES 560122* -- Radiation Effects on Cells-- Internal Source-- (-1987); 560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)