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Title: Robotics for recombinant DNA and human genetics research

In October of 1989, molecular biologists throughout the world formally embarked on ultimately determining the set of genetic instructions for a human being. Called by some the Manhattan Project'' a molecular biology, pursuit of this goal is projected to require approximately 3000 man years of effort over a 15-year period. The Humane Genome Initiative is a worldwide research effort that has the goal of analyzing the structure of human deoxyribonucleic acid (DNA) and determining the location of all human genes. The Department of Energy (DOE) has designated three of its national laboratories as centers for the Human Genome Project. These are Los Alamos National Laboratory (LANL), Lawrence Livermore National Laboratory (LLNL), and Lawrence Berkeley Laboratory (LBL). These laboratories are currently working on different, but complementary technology development areas in support of the Human Genome Project. The robotics group at LANL is currently working at developing the technologies that address the problems associated with physical mapping. This article describes some of these problems and discusses some of the robotics approaches and engineering tolls applicable to their solution. 7 refs., 8 figs., 1 tab.
Authors:
Publication Date:
OSTI Identifier:
5894655
Report Number(s):
LA-UR-90-2884; CONF-910637--1
ON: DE90016440
DOE Contract Number:
W-7405-ENG-36
Resource Type:
Conference
Resource Relation:
Conference: 5. international conference on advanced robotics, Pisa (Italy), 20-22 Jun 1991
Research Org:
Los Alamos National Lab., NM (USA)
Sponsoring Org:
DOE; USDOE, Washington, DC (USA)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; CHROMOSOMES; GENETIC MAPPING; GENETICS; RESEARCH PROGRAMS; MAN; MOLECULAR BIOLOGY; ROBOTS; AUTOMATION; DIAGNOSTIC USES; DNA HYBRIDIZATION; DNA SEQUENCING; HEREDITARY DISEASES; RECOMBINANT DNA; THERAPEUTIC USES; THERAPY; ANIMALS; BIOLOGY; DISEASES; DNA; HYBRIDIZATION; MAMMALS; MAPPING; NUCLEIC ACIDS; ORGANIC COMPOUNDS; PRIMATES; STRUCTURAL CHEMICAL ANALYSIS; USES; VERTEBRATES 550400* -- Genetics; 550200 -- Biochemistry