The observed relationship between the occurrence of acute radiation effects and leukemia mortality among A-bomb survivors

Journal Article · Fri Feb 01 00:00:00 EST 1991 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577889· OSTI ID:5891478

Neriishi, K; Stram, D O; Vaeth, M; Mizuno, S; Akiba, S ^[1]

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1. Radiation Effects Research Foundation, Hiroshima (Japan)

In an analysis of a follow-up study of a fixed population of 73,330 atomic bomb survivors in Hiroshima and Nagasaki, the slope of an estimated dose response between ionizing radiation and leukemia mortality was found to be steeper (P less than 0.002), by a factor of 2.4, among those who reported epilation within 60 days of the bombings, compared to those who did not experience this sign of acute radiation exposure. The strength of this empirical finding as evidence of biological association in individual radiosensitivity for these two end points is studied here. The major factor complicating the interpretation of this finding as evidence of such an association is the degree of imprecision of the radiation dosimetry system used in assignment of radiation doses to the A-bomb survivors. Using models recently suggested for dealing with dosimetry errors in epidemiological analysis of the A-bomb survivor data, the sensitivity of the apparent association between leukemia mortality and severe epilation to the assumed level of dosimetry error is investigated.

• OSTI ID: 5891478
• Journal Information: Radiation Research; (USA), Vol. 125:2; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
A-BOMB SURVIVORS
MORTALITY
DOSIMETRY
MATHEMATICAL MODELS
LEUKEMIA
RADIOINDUCTION
ACUTE EXPOSURE
BIOLOGICAL RADIATION EFFECTS
DATA COVARIANCES
DOSE-RESPONSE RELATIONSHIPS
HIROSHIMA
IONIZING RADIATIONS
NAGASAKI
RADIATION INJURIES
ASIA
BIOLOGICAL EFFECTS
DISEASES
HEMIC DISEASES
HUMAN POPULATIONS
IMMUNE SYSTEM DISEASES
INJURIES
JAPAN
NEOPLASMS
POPULATIONS
RADIATION EFFECTS
RADIATIONS
560151* - Radiation Effects on Animals- Man