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Title: Effect of cyclophosphamide and electromagnetic fields on mouse bone marrow

The authors have previously shown that the exposure to low frequency pulsing electromagnetic fields (PEMF) of mice X-ray irradiated resulted in an increased damage to the bone marrow. The series of experiments here reported were designed to investigate the effect of PEMF exposure after intraperitoneum injection of 200mg/kg of cyclophosphamide (CY). Control mice were CY injected only; experimental mice were CY injected and then exposed to PEMF. Exposure to PEMF (24 hours/day) increased the rate of decline of white blood cells in peripheral blood. Spleen weight was statistically higher among control mice than among mice exposed to PEMF at day 6, 8 and 10 after CY injection. Spleen autoradiography proved to be higher among PEMF exposed mice than among controls at day 8 and 9 after CY injection. The grafting efficiency of the bone marrow obtained from control mice was higher than the grafting efficiency of the bone marrow recovered from mice exposed to PEMF. All these data indicate that the exposure to PEMF increases the cytotoxic effect of CY.
Authors:
; ; ;  [1]
  1. (Univ. di Modena (Italy))
Publication Date:
OSTI Identifier:
5891399
Report Number(s):
CONF-9104107--
Journal ID: ISSN 0892-6638; CODEN: FAJOE
Resource Type:
Conference
Resource Relation:
Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States); Journal Volume: 4:3; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ELECTROMAGNETIC FIELDS; TOXICITY; ENDOXAN; AUTORADIOGRAPHY; BONE MARROW; GRAFTS; IMMUNOSUPPRESSION; LEUKOCYTES; MICE; SPLEEN; ALKYLATING AGENTS; ANIMAL TISSUES; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; DRUGS; HEMATOPOIETIC SYSTEM; IMMUNOSUPPRESSIVE DRUGS; MAMMALS; MATERIALS; ORGANS; RODENTS; TISSUES; TRANSPLANTS; VERTEBRATES 560400* -- Other Environmental Pollutant Effects