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Title: Photochemical reaction cycle of bacteriorhodopsin

Abstract

The complex spectroscopic transformations during the reaction cycle of the light-driven proton pump, bacteriorhodopsin, are satisfactorily explained with a single-photoreaction scheme, which contains reversible reactions. The proposed model, derived by fitting time-resolved difference spectra, is BR {yields}{sup hv} K {leftrightarrow} L {leftrightarrow} M{sub 1} {yields} M{sub 2} {leftrightarrow} N {leftrightarrow} O {yields} BR. Some of these reactions are correlated with retinal bond motions, others with proton transfers internal and external to the protein. Thermodynamic analysis indicates that mechanistic coupling to proton potential is at the M{sub 1} {yields} M{sub 2} step, which also functions as the switch that confers direction to the net proton translocation. 92 refs., 5 figs.

Authors:
 [1]
  1. Univ. of California, Irvine, CA (United States)
Publication Date:
OSTI Identifier:
588732
Report Number(s):
CONF-910812-
CNN: Grant GM 29498;Grant NAGW-212; TRN: 98:001295-0002
Resource Type:
Conference
Resource Relation:
Conference: 202. national meeting of the American Chemical Society (ACS), New York, NY (United States), 25-30 Aug 1991; Other Information: PBD: 1994; Related Information: Is Part Of Molecular and biomolecular electronics; Birge, R.R. [ed.]; PB: 585 p.
Country of Publication:
United States
Language:
English
Subject:
40 CHEMISTRY; 55 BIOLOGY AND MEDICINE, BASIC STUDIES; PROTEINS; RHODOPSIN; PHOTOCHEMISTRY; PHOTOCHEMICAL REACTIONS; CELL CYCLE; MATHEMATICAL MODELS; PROTONS; BACTERIA; CHEMICAL BONDS; STRUCTURE-ACTIVITY RELATIONSHIPS; RAMAN SPECTRA; CHEMICAL REACTION KINETICS; FUNCTIONAL MODELS; THERMODYNAMICS

Citation Formats

Lanyi, J K. Photochemical reaction cycle of bacteriorhodopsin. United States: N. p., 1994. Web.
Lanyi, J K. Photochemical reaction cycle of bacteriorhodopsin. United States.
Lanyi, J K. 1994. "Photochemical reaction cycle of bacteriorhodopsin". United States.
@article{osti_588732,
title = {Photochemical reaction cycle of bacteriorhodopsin},
author = {Lanyi, J K},
abstractNote = {The complex spectroscopic transformations during the reaction cycle of the light-driven proton pump, bacteriorhodopsin, are satisfactorily explained with a single-photoreaction scheme, which contains reversible reactions. The proposed model, derived by fitting time-resolved difference spectra, is BR {yields}{sup hv} K {leftrightarrow} L {leftrightarrow} M{sub 1} {yields} M{sub 2} {leftrightarrow} N {leftrightarrow} O {yields} BR. Some of these reactions are correlated with retinal bond motions, others with proton transfers internal and external to the protein. Thermodynamic analysis indicates that mechanistic coupling to proton potential is at the M{sub 1} {yields} M{sub 2} step, which also functions as the switch that confers direction to the net proton translocation. 92 refs., 5 figs.},
doi = {},
url = {https://www.osti.gov/biblio/588732}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Dec 31 00:00:00 EST 1994},
month = {Sat Dec 31 00:00:00 EST 1994}
}

Conference:
Other availability
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