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Title: Improved survival of newborns receiving leukocyte transfusions for sepsis

Abstract

To determine the role of polymorphonuclear (PMN) leukocyte transfusions in neonates with sepsis, 23 consecutive newborns were prospectively randomly selected during an 18-month period in a treatment plan to receive polymorphonuclear leukocyte transfusions with supportive care or supportive care alone. Thirteen neonates received transfusions every 12 hours for a total of five transfusions. Each transfusion consisting of 15 mL/kg of polymorphonuclear leukocytes was subjected to 1,500 rads of radiation. The polymorphonuclear leukocytes were obtained by continuous-flow centrifugation leukapheresis and contained 0.5 to 1.0 X 10(9) granulocytes per 15 mL with less than 10% lymphocytes. Positive findings on blood cultures were obtained in 14/23 patients and seven were randomly selected for each treatment group. Absolute granulocyte counts were less than 1,500/microL in 13 patients but tibial bone marrow examinations revealed that the neutrophil supply pool was depleted in only three patients. The survival was significantly greater in the treatment group compared with the group that did not receive transfusions.

Authors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
Univ. of California, Irvine
OSTI Identifier:
5886043
Resource Type:
Journal Article
Journal Name:
Pediatrics; (United States)
Additional Journal Information:
Journal Volume: 74:5
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BACTERIAL DISEASES; THERAPY; LEUKOCYTES; BIOLOGICAL RADIATION EFFECTS; BONE MARROW; NEONATES; SURVIVAL CURVES; TRANSFUSIONS; ANIMAL TISSUES; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; DISEASES; HEMATOPOIETIC SYSTEM; INFECTIOUS DISEASES; MATERIALS; ORGANS; RADIATION EFFECTS; TISSUES; 560121* - Radiation Effects on Cells- External Source- (-1987)

Citation Formats

Cairo, M S, Rucker, R, Bennetts, G A, Hicks, D, Worcester, C, Amlie, R, Johnson, S, and Katz, J. Improved survival of newborns receiving leukocyte transfusions for sepsis. United States: N. p., 1984. Web.
Cairo, M S, Rucker, R, Bennetts, G A, Hicks, D, Worcester, C, Amlie, R, Johnson, S, & Katz, J. Improved survival of newborns receiving leukocyte transfusions for sepsis. United States.
Cairo, M S, Rucker, R, Bennetts, G A, Hicks, D, Worcester, C, Amlie, R, Johnson, S, and Katz, J. 1984. "Improved survival of newborns receiving leukocyte transfusions for sepsis". United States.
@article{osti_5886043,
title = {Improved survival of newborns receiving leukocyte transfusions for sepsis},
author = {Cairo, M S and Rucker, R and Bennetts, G A and Hicks, D and Worcester, C and Amlie, R and Johnson, S and Katz, J},
abstractNote = {To determine the role of polymorphonuclear (PMN) leukocyte transfusions in neonates with sepsis, 23 consecutive newborns were prospectively randomly selected during an 18-month period in a treatment plan to receive polymorphonuclear leukocyte transfusions with supportive care or supportive care alone. Thirteen neonates received transfusions every 12 hours for a total of five transfusions. Each transfusion consisting of 15 mL/kg of polymorphonuclear leukocytes was subjected to 1,500 rads of radiation. The polymorphonuclear leukocytes were obtained by continuous-flow centrifugation leukapheresis and contained 0.5 to 1.0 X 10(9) granulocytes per 15 mL with less than 10% lymphocytes. Positive findings on blood cultures were obtained in 14/23 patients and seven were randomly selected for each treatment group. Absolute granulocyte counts were less than 1,500/microL in 13 patients but tibial bone marrow examinations revealed that the neutrophil supply pool was depleted in only three patients. The survival was significantly greater in the treatment group compared with the group that did not receive transfusions.},
doi = {},
url = {https://www.osti.gov/biblio/5886043}, journal = {Pediatrics; (United States)},
number = ,
volume = 74:5,
place = {United States},
year = {Thu Nov 01 00:00:00 EST 1984},
month = {Thu Nov 01 00:00:00 EST 1984}
}