Effects of cadmium, calcium, age and parity on bone mineral, density and strength in female rats
Weanling female rats were fed diets containing one of three levels of Ca (0.3, 0.6, or 0.9%) and one of four levels of Cd (0, 1, 5, or 10 ppm) in the drinking water. One half of each group was fed first as adolescents (55 days) and the other half as mature (110 days) females. Approximately 10 animals from each group were sacrificed after the first pregnancy and the remaining animals after the fourth pregnancy. Reproductive performance, plasma and bone Ca and P and bone density and strength were measured. After the first pregnancy, offspring of dams treated with 5 or 10 ppm Cd were smaller at birth than offspring of dams treated with 0 or 1 ppm Cd. After the fourth pregnancy, the decreased birth weight was evident only in offspring of dams treated with 10 ppm Cd. Offspring of dams fed 5 or 10 ppm Cd or the 0.3% Ca diet had decreased weaning weight regardless of parity. A 0.3% Ca diet superimposed upon a 5 or 10 ppm Cd intake decreased weaning weight of the male offspring after the first, but not the fourth, pregnancy with the offspring of adolescent dams affected more than those of mature dams. Offspring of dams fed the 0.9% Ca diet did not differ in weaning weight from the offspring of dams fed the 0.6% Ca diet. The 0.3% Ca diet depressed the plasma Ca and the 0.9% Ca diet elevated the plasma Ca and depressed the plasma P when compared to the 0.6% diet.
- Research Organization:
- Tennessee Univ., Knoxville (USA)
- OSTI ID:
- 5884411
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM
TISSUE DISTRIBUTION
TOXICITY
CALCIUM
AGE DEPENDENCE
ANIMAL GROWTH
DENSITY
FEMALES
INGESTION
PHOSPHORUS
PREGNANCY
RATS
SKELETON
ALKALINE EARTH METALS
ANIMALS
BODY
DISTRIBUTION
ELEMENTS
GROWTH
INTAKE
MAMMALS
METALS
NONMETALS
ORGANS
PHYSICAL PROPERTIES
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)