Stereochemical studies in the development of technetium radiopharmaceuticals. 1. Fluxional racemization of technetium and rhenium penicillamine complexes
Rhenium and technetium penicillamine complexes have been synthesized by SnCl/sub 2/ reduction of ReO/sub 4//sup -/ or TcO/sub 4//sup -/ in the presence of optically pure or racemic penicillamine. The complexes are characterized by their chromatographic behavior, electronic spectra, fast atom bombardment mass spectra, and variable temperature /sup 1/H NMR spectra. All complexes are six-coordinate in solution, with one tridentate penicillamine, one bidentate penicillamine, and one oxo ligand. The mixed complexes are functional, racemizing by exchange of carboxylates at the sites trans to the oxo ligand. Kinetics of this process were measured by complete line-shape analysis of the NMR spectra, and values for reaction rate constants are reported.
- Research Organization:
- Univ. of Utah, Salt Lake City
- DOE Contract Number:
- AC02-82ER60048; AC02-83ER60140
- OSTI ID:
- 5883118
- Journal Information:
- Inorg. Chem.; (United States), Vol. 23:25
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
PENICILLAMINE
RACEMIZATION
RHENIUM COMPLEXES
CHEMICAL PREPARATION
TECHNETIUM COMPLEXES
RADIOPHARMACEUTICALS
STEREOCHEMISTRY
TECHNETIUM 99
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHELATING AGENTS
COMPLEXES
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
SYNTHESIS
TECHNETIUM ISOTOPES
THIOLS
TRANSITION ELEMENT COMPLEXES
YEARS LIVING RADIOISOTOPES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
400301 - Organic Chemistry- Chemical & Physicochemical Properties- (-1987)