Comparative analysis of the interaction of various estrogens with the estrogen-receptor system of the uterus

Journal Article · Tue May 20 00:00:00 EDT 1986 · Biochemistry (Engl. Transl.); (United States)

OSTI ID:5878804

Fanchenko, N D; Alekseeva, M L; Minina, L S; Novikov, E A; Khel'mun, D K

The binding of various labeled estrogens under conditions of equilibrium in the cytosol of the uterus of sexually immature Wistar rats was studied. An analysis of the data obtained, as well as the kinetics of the dissociation of the complexes of the ligands used with specific high-affinity estrogen-binding sites of the cytosol, suggested that the population of estrogen receptors in the rat uterus is homogeneous. The possibility of intracellular regulation of the action of estrogens in the target cell in the presence of a homogeneous population of receptors, both at the receptor and at the post-receptor stages, is suggested.

• Research Organization: Ministry of Health of the USSR, Moscow
• OSTI ID: 5878804
• Journal Information: Biochemistry (Engl. Transl.); (United States), Vol. 50:11; Other Information: Translated from Biokhimiya; 50: No. 11, 1853-1858(Nov 1985)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ESTROGENS
BIOCHEMISTRY
RECEPTORS
UTERUS
RADIORECEPTOR ASSAY
BINDING ENERGY
BIOCHEMICAL REACTION KINETICS
CYTOLOGY
LABELLING
RADIOACTIVITY
RATS
STILBESTROL
TRITIUM COMPOUNDS
ANIMALS
AROMATICS
BIOLOGY
BODY
CHEMISTRY
ENERGY
FEMALE GENITALS
HORMONES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PROTEINS
REACTION KINETICS
RODENTS
STEROID HORMONES
TRACER TECHNIQUES
VERTEBRATES
550301* - Cytology- Tracer Techniques
550201 - Biochemistry- Tracer Techniques