Altered in vitro uptake of the radiolabelled antiviral imaging probe E-5-(2-125-iodovinyl)-2'-deoxyuridine following administration of acyclovir
Current developments in the use of radiolabelled antiviral drugs as specific probes for virus-infected cells in vivo may allow the specific neuroradiological diagnosis of herpes encephalitis. As blind therapy with the antiviral drug acyclovir may precede specific neuroradiological diagnosis, the aim of the present study was to investigate whether or not acyclovir interferes with the uptake of the radioprobe E-5-(2-125-Iodovinyl)-2'-deoxyuridine (rIVDU) by virus-infected cells in vitro. Acyclovir treatment (0.1 to 10 micrograms/ml) was shown to increase initial radioprobe uptake by virus-infected cells. However, with continued incubation in the presence of acyclovir, intracellular radioactivity decreased to a level not significantly different from that associated with noninfected cells. A mechanism to explain these results is proposed. It was concluded that concurrent acyclovir therapy could interfere with neuroradiological diagnosis using rIVDU, although this may not occur with all the candidate radioprobes currently under investigation.
- Research Organization:
- Univ. of Manchester (England)
- OSTI ID:
- 5877833
- Journal Information:
- J. Med. Virol.; (United States), Vol. 28:1
- Country of Publication:
- United States
- Language:
- English
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ANTIMICROBIAL AGENTS
BIOCHEMICAL REACTION KINETICS
RADIOPHARMACEUTICALS
UPTAKE
VIRAL DISEASES
DIAGNOSIS
DATA COVARIANCES
DEOXYURIDINE
IN VITRO
IODINE 125
ANTI-INFECTIVE AGENTS
ANTIMETABOLITES
AZINES
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIOISOTOPES
REACTION KINETICS
RIBOSIDES
URACILS
550601* - Medicine- Unsealed Radionuclides in Diagnostics