System identification and compartmental analysis of left heart by first-pass radionuclide angiography
This project was undertaken to develop a rigorous method to quantitate valvular regurgitation and other hemodynamic parameters and to evaluate its clinical applicability. First-pass pulmonary time-activity curves were used as system input functions and left ventricular curves as output functions of differential equations describing both 1 and 2 compartment systems. The 2 models were applied in 34 patients (PTS): 16 with mitral regurgitation and 18 without regurgitation. The one and 2 compartment models gave similar forward ejection fraction values (r=.89 with similar means). The 2 compartment model yielded RF of 6 +- 8% in PTS without regurgitation vs. 39 +- 22% in PTS with regurgitation (p<.01). RF correlated well with the severity of regurgitation by contrast angiography. These identification methods provide a new approach to the determination of regurgitant fraction and other hemodynamic parameters, yielding results that correlate well with other clinical and angiographic findings and that also supplement and extend the results of gated cardiac imaging. The 1 and 2 compartment models yield complimentary results.
- Research Organization:
- Saint John's Hospital and Health Center, Santa Monica, CA
- OSTI ID:
- 5872630
- Report Number(s):
- CONF-850611-; TRN: 87-039580
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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BIOMEDICAL RADIOGRAPHY
IMAGE PROCESSING
CARDIOGRAPHY
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BLOOD FLOW
DYNAMIC FUNCTION STUDIES
RADIOISOTOPE SCANNING
BLOOD VESSELS
DIAGNOSTIC TECHNIQUES
LABELLED POOL TECHNIQUES
LEAST SQUARE FIT
RADIOCARDIOGRAPHY
SCINTISCANNING
TIME DEPENDENCE
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CARDIOVASCULAR SYSTEM
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ISOTOPE APPLICATIONS
MAXIMUM-LIKELIHOOD FIT
MEDICINE
NUCLEAR MEDICINE
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ORGANS
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