Molecular target size of the vanilloid (capsaicin) receptor in pig dorsal root ganglia

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(91)90242-4· OSTI ID:5857567

Szallasi, A; Blumberg, P M ^[1]

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1. National Cancer Institute, Bethesda, MD (USA)

The size of the vanilloid receptor was examined by high-energy radiation inactivation analysis of the binding of ({sup 3}H)resiniferatoxin to pig dorsal root ganglion membranes; it was found to be 270 {plus minus} 25 kDa. This value most likely represents the size of a receptor complex rather than of an individual subunit. Other ligand-gated cation channel complexes have reported molecular weights in this range, e.g. 300 kDa for the acetylcholine receptor.

• OSTI ID: 5857567
• Journal Information: Life Sciences; (USA), Vol. 48:19; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PROTEINS
RECEPTORS
CHEMICAL COMPOSITION
BIOCHEMICAL REACTION KINETICS
CAPSICUM
CELL MEMBRANES
IONIZING RADIATIONS
MOLECULAR WEIGHT
NERVE CELLS
SWINE
TOXINS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMAL CELLS
ANIMALS
ANTIGENS
CELL CONSTITUENTS
DOMESTIC ANIMALS
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
MAGNOLIOPHYTA
MAGNOLIOPSIDA
MAMMALS
MATERIALS
MEMBRANE PROTEINS
MEMBRANES
ORGANIC COMPOUNDS
PLANTS
RADIATIONS
REACTION KINETICS
SOMATIC CELLS
TOXIC MATERIALS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
560120 - Radiation Effects on Biochemicals
Cells
& Tissue Culture