Effects of ionizing radiation on cells from Fanconi's anemia patients
The lymphocytes from some Fanconi's anemia patients appeared to be more radiosensitive than normal as measured by the number of X-ray-(or bleomycin-) induced chromosome aberrations seen following G2 treatment. Fibroblasts from the same patients, however, all showed the same degree of colony survival as normals following exposure to gamma-rays (Do, 1.13 +/- 0.072 (S.E.) Gy and 1.14 +/- 0.077 Gy for Fanconi's anemia and normal fibroblasts, respectively). The lack of increased radiosensitivity in Fanconi's fibroblasts was also observed by the same degree of inhibition of DNA synthesis as seen in normals following gamma-irradiation. The results show clearly that there is no increase in radiosensitivity common to all cell types from Fanconi's patients, although an apparent increase in chromosomal radiosensitivity may be seen in the lymphocytes from an occasional patient.
- Research Organization:
- Medical School, Birmingham, England
- OSTI ID:
- 5854702
- Journal Information:
- Cancer Res.; (United States), Vol. 45:1
- Country of Publication:
- United States
- Language:
- English
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Increased radiosensitivity of a subpopulation ot T-lymphocyte progenitors from patients with Fanconi's anemia
Increased radiosensitivity of a subpopulation of T-lymphocyte progenitors from patients with Fanconi's anemia
Related Subjects
FIBROBLASTS
GENETIC RADIATION EFFECTS
RADIOSENSITIVITY
LYMPHOCYTES
ANEMIAS
BLEOMYCIN
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
DNA REPLICATION
GAMMA RADIATION
PATIENTS
SURVIVAL TIME
X RADIATION
ANIMAL CELLS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
GENETIC EFFECTS
HEMIC DISEASES
IONIZING RADIATIONS
LEUKOCYTES
MATERIALS
MUTATIONS
NUCLEIC ACID REPLICATION
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
SYMPTOMS
560121* - Radiation Effects on Cells- External Source- (-1987)