Cysteamine blocks somatostatin secretion without altering the course of insulin or glucagon release. A new model for the study of islet function

Journal Article · Fri Apr 01 00:00:00 EST 1983 · Diabetes; (United States)

DOI:https://doi.org/10.2337/diab.32.4.377· OSTI ID:5852609

Sorenson, R L; Grouse, L H; Elde, R P

Cysteamine (300 mg/kg) administered subcutaneously depletes pancreatic somatostatin to 36% of control levels, but does not alter pancreatic insulin or glucagon content. Although perfusion of pancreata from normal animals with glucose (300 mg/dl) markedly stimulated somatostatin release, pancreata from cysteamine-treated animals failed to secrete somatostatin in response to glucose. Cysteamine treatment was without effect on insulin and glucagon release under the conditions tested. The isolated perfused pancreas from the cysteamine-treated rat provides a model for further investigations into regulation of islet hormone release in the absence of stimulated somatostatin release.

• Research Organization: Department of Anatomy, University of Minnesota Medical School, Minneapolis
• OSTI ID: 5852609
• Journal Information: Diabetes; (United States), Vol. 32:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
MEA
BIOLOGICAL EFFECTS
SOMATOSTATIN
INHIBITION
BIOLOGICAL MODELS
GLUCAGON
INSULIN
PANCREAS
PHYSIOLOGY
RATS
AMINES
ANIMALS
BODY
DIGESTIVE SYSTEM
DRUGS
ENDOCRINE GLANDS
GLANDS
HORMONES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RODENTS
THIOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
551000 - Physiological Systems