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Title: Synthesis of N-unsubstituted and N-methyl derivatives of 4-aryl-2,6-dimethyl-1,2-dihydropyridine-3,5-dicarbonitriles

In the reduction of 2,6-dimethyl-4-arylpyridine-3,5-dicarbonitriles or their N-oxides by sodium borohydride, a mixture of 1,2- and 1,4-dihydropyridine-3,5-dicarbonitriles is formed. 1,2,6-Trimethyl-4-aryl-1,2-dihydropyridine-3,5-dicarbonitriles were obtained by reducing the corresponding pyridinium perchlorates or by alkylating 4-acryl-2,6-dimethyl-1,2-dihydropyridine-3,5-dicarbonitrile derivatives by methyl iodide.
Authors:
; ; ;
Publication Date:
OSTI Identifier:
5852082
Resource Type:
Journal Article
Resource Relation:
Journal Name: Chem. Heterocycl. Compd. (Engl. Transl.); (United States); Journal Volume: 23:1; Other Information: Translated from Khim. Geterotsikl. Soedin.; 23: No. 1, 81-85(Jan 1987)
Research Org:
Institute of Organic Synthesis, Riga, USSR
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 74 ATOMIC AND MOLECULAR PHYSICS; BOROHYDRIDES; CATALYTIC EFFECTS; METHYL IODIDE; NITRILES; NMR SPECTRA; SYNTHESIS; PYRIDINES; SODIUM COMPOUNDS; ALKYLATING AGENTS; CHEMICAL SHIFT; COUPLING CONSTANTS; INFRARED SPECTRA; J-J COUPLING; METHYLATION; MULTIPLETS; REDUCING AGENTS; REDUCTION; ULTRAVIOLET SPECTRA; ALKALI METAL COMPOUNDS; AZINES; BORON COMPOUNDS; CHEMICAL REACTIONS; COUPLING; HALOGENATED ALIPHATIC HYDROCARBONS; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; INTERMEDIATE COUPLING; IODINATED ALIPHATIC HYDROCARBONS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; SPECTRA 400201* -- Chemical & Physicochemical Properties; 640302 -- Atomic, Molecular & Chemical Physics-- Atomic & Molecular Properties & Theory