Histaminergic neurons in the hypothalamic thermoregulatory pathways
Based on neurochemical and neurophysiological research, especially over the past decade, considerable evidence exists for accepting histamine as a central neurotransmitter alongside the other neuroamines. The data supporting a functional role are not complete, but they do exhibit a consistent pattern in the case of the central thermoregulatory pathways. Thus, the region of the thermoregulatory centers in the rostral hypothalamus contains relatively high concentrations of histamine and the enzyme systems for its synthesis and degradation: degeneration studies indicate histaminergic pathways in the hypothalamus; thermoregulatory changes can be induced by activation of either H/sub 1/ or H/sub 2/ receptors; behavioral studies reveal different functional roles for H/sub 1/ and H/sub 2/ receptors; and the thermoregulatory responses to histamine are detectable across different species, even in nonhomeothermic animals. This evidence supports assigning a transmitter function to histamine in the central thermoregulatory pathways that would appear to be as well-founded as the comparable data amassed for other neuroamines.
- Research Organization:
- Univ. of California, Los Angeles
- OSTI ID:
- 5851265
- Journal Information:
- Fed. Proc.; (United States), Vol. 40:13; Conference: The newer putative central neurotransmitters: role in thermoregulation, Atlanta, GA, 14 Apr 1981
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
HISTAMINE
BIOSYNTHESIS
DECOMPOSITION
THERMOREGULATION
BIOLOGICAL PATHWAYS
NEUROREGULATORS
EXPERIMENTAL DATA
FISHES
HYPOTHALAMUS
NERVE CELLS
AMINES
ANIMAL CELLS
ANIMALS
AQUATIC ORGANISMS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZOLES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMICAL REACTIONS
CONTROL
DATA
DRUGS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INFORMATION
NERVOUS SYSTEM
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
SOMATIC CELLS
SYNTHESIS
TEMPERATURE CONTROL
VERTEBRATES
560205* - Thermal Effects- Vertebrates- (-1987)
550100 - Behavioral Biology