New metabolic pathway for N,N-dimethyltryptamine

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Biol. Psychiatry; (United States)

DOI:https://doi.org/10.1016/0006-3223(86)90010-7· OSTI ID:5842952

Hryhorczuk, L M; Rainey, Jr, J M; Frohman, C E; Novak, E A

N,N-Dimethyltryptamine (DMT) undergoes a major structural alteration when added to whole human blood or its red blood cells in vitro. A new high-pressure liquid chromatography (HPLC) peak is present in extracts of these treated tissues. The compound responsible for this peak has been identified by ultraviolet spectrophotometry and by mass spectrometry as dimethylkynuramine (DMK). The enzyme responsible for this appears to be different from tryptophan 2,3-dioxygenase and also from indoleamine 2,3-dioxygenase.

• Research Organization: Lafayette Clinic, Detroit, MI
• OSTI ID: 5842952
• Journal Information: Biol. Psychiatry; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
TRYPTAMINES
BIOLOGICAL PATHWAYS
METABOLISM
ERYTHROCYTES
IN VITRO
OXYGENASES
PLASMA
AMINES
AROMATICS
AZAARENES
AZOLES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
ENZYMES
HETEROCYCLIC COMPOUNDS
INDOLES
MATERIALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PYRROLES
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)