Tear and serum IgE concentrations by Tandem-R IgE immunoradiometric assay in allergic patients

Journal Article · Sat Aug 01 00:00:00 EDT 1987 · Ophthalmology (Rochester, Minn.); (United States)

DOI:https://doi.org/10.1016/S0161-6420(87)33355-X· OSTI ID:5842109

Insler, M S; Lim, J M; Queng, J T; Wanissorn, C; McGovern, J P

The authors studied a population of 39 allergic and 15 nonallergic patients, and determined their tear and serum IgE concentrations. Samples of tear and serum were tested for IgE by the Tandem-R immunoradiometric assay, which uses monoclonal antibody to produce a specific assay for IgE. The serum IgE levels in the study group showed a range from 23,280 to 16 IU/ml compared with controls of 72 to 2 IU/ml. Tear IgE in the study group varied from 159 IU/ml to less than 1 IU/ml compared with controls of 8 IU/ml to less than 1 IU/ml. A statistically significant correlation between tear and serum IgE exists in the allergic patients with eye symptoms. It also exists when serum IgE was greater than 100 IU/ml, the tear IgE greater than 4 IU/ml, or when both the serum IgE was greater than 100 IU/ml and the tear IgE greater than 4 IU/ml.

• Research Organization: LSU Eye Center, New Orleans
• OSTI ID: 5842109
• Journal Information: Ophthalmology (Rochester, Minn.); (United States), Vol. 94:8
• Country of Publication: United States
• Language: English

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