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Title: Amino acids as central synaptic transmitters or modulators in mammalian thermoregulation

Abstract

Of the amino acids that affect the activity of central neurons, aspartate and glutamate (which exert generally excitatory influences) and glycine, taurine, and ..gamma..-aminobutyric acid (GABA) (which generally exert inhibitory influences) are the strongest neurotransmitter candidates. As with other putative transmitter substances, their effects on body temperature when injected into the cerebral ventricles or the preoptic hypothalamus tend to vary within and between species. These effects are uninterpretable without accompanying information regarding effector activity changes and the influences of dose and ambient temperature. Observations necessary for analysis of apparent action have been made in studies of the effects of intracerebroventricular injections of these amino acids into sheep. Aspartate and glutamate have similar excitatory effects on the pathway from cold sensors, whereas taurine and GABA exert inhibitory influences on the neural pathways that activate both heat production and heat loss effectors. Glycine appears to be without effect.

Authors:
Publication Date:
Research Org.:
Univ. of Alaska, Fairbanks
OSTI Identifier:
5841533
Resource Type:
Conference
Journal Name:
Fed. Proc.; (United States)
Additional Journal Information:
Journal Volume: 40:3; Conference: Newer putative central neurotransmitters: roles in thermoregulation, Atlanta, GA, USA, 14 Apr 1981
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; NEUROREGULATORS; DYNAMIC FUNCTION STUDIES; THERMOREGULATION; BIOLOGICAL PATHWAYS; AMINO ACIDS; CEREBRUM; HYPOTHALAMUS; NERVE CELLS; SHEEP; ANIMAL CELLS; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; BRAIN; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; CONTROL; DOMESTIC ANIMALS; DRUGS; MAMMALS; NERVOUS SYSTEM; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RUMINANTS; SOMATIC CELLS; TEMPERATURE CONTROL; VERTEBRATES; 560205* - Thermal Effects- Vertebrates- (-1987); 550100 - Behavioral Biology

Citation Formats

Bligh, J. Amino acids as central synaptic transmitters or modulators in mammalian thermoregulation. United States: N. p., 1981. Web.
Bligh, J. Amino acids as central synaptic transmitters or modulators in mammalian thermoregulation. United States.
Bligh, J. 1981. "Amino acids as central synaptic transmitters or modulators in mammalian thermoregulation". United States.
@article{osti_5841533,
title = {Amino acids as central synaptic transmitters or modulators in mammalian thermoregulation},
author = {Bligh, J},
abstractNote = {Of the amino acids that affect the activity of central neurons, aspartate and glutamate (which exert generally excitatory influences) and glycine, taurine, and ..gamma..-aminobutyric acid (GABA) (which generally exert inhibitory influences) are the strongest neurotransmitter candidates. As with other putative transmitter substances, their effects on body temperature when injected into the cerebral ventricles or the preoptic hypothalamus tend to vary within and between species. These effects are uninterpretable without accompanying information regarding effector activity changes and the influences of dose and ambient temperature. Observations necessary for analysis of apparent action have been made in studies of the effects of intracerebroventricular injections of these amino acids into sheep. Aspartate and glutamate have similar excitatory effects on the pathway from cold sensors, whereas taurine and GABA exert inhibitory influences on the neural pathways that activate both heat production and heat loss effectors. Glycine appears to be without effect.},
doi = {},
url = {https://www.osti.gov/biblio/5841533}, journal = {Fed. Proc.; (United States)},
number = ,
volume = 40:3,
place = {United States},
year = {Sun Nov 01 00:00:00 EST 1981},
month = {Sun Nov 01 00:00:00 EST 1981}
}

Conference:
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