Synovectomy of the rheumatoid knee using intra-articular injection of dysprosium-165-ferric hydroxide macroaggregates

Journal Article · Tue Sep 01 00:00:00 EDT 1987 · J. Bone Jt. Surg., Am. Vol.; (United States)

OSTI ID:5840582

Sledge, C B; Zuckerman, J D; Shortkroff, S; Zalutsky, M R; Venkatesan, P; Snyder, M A; Barrett, W P

One hundred and eleven patients who had seropositive rheumatoid arthritis and persistent synovitis of the knee were treated with intra-articular injection of 270 millicuries of dysprosium-165 bound to ferric hydroxide macroaggregates. A two-year follow-up was available for fifty-nine of the treated knees. Thirty-nine had a good result; nine, a fair result; and eleven, a poor result. Of the twenty-five knees that had Stage-I radiographic changes, nineteen had a good result. Of the thirty-four knees that had Stage-II radiographic changes, twenty showed a good result. Systemic spread of the radioactivity from the injected joint was minimum. The mean whole-body dose was calculated to be 0.3 rad and that to the liver twenty-four hours after injection, 3.2 rads. The results indicated that dysprosium-165-ferric hydroxide macroaggregate is an effective agent for performing radiation synovectomy, particularly in knees that have Stage-I radiographic changes. Because of the minimum rate of systemic spread of the dysprosium-165, it offers a definite advantage over agents that previously have been used.

• Research Organization: Brigham and Women's Hospital, Boston, MA
• OSTI ID: 5840582
• Journal Information: J. Bone Jt. Surg., Am. Vol.; (United States), Vol. 69:7
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BONE JOINTS
RADIATION DOSES
RHEUMATIC DISEASES
RADIOTHERAPY
DYSPROSIUM 165
IRON HYDROXIDES
PATIENTS
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DISEASES
DOSES
DYSPROSIUM ISOTOPES
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
HYDROXIDES
INTERMEDIATE MASS NUCLEI
IRON COMPOUNDS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPES
RADIOLOGY
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
SKELETAL DISEASES
SKELETON
THERAPY
TRANSITION ELEMENT COMPOUNDS
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)