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Title: Skin blood flow in sheep: comparison of xenon-133 washout and radioactive microsphere techniques

Abstract

Blood flow was measured in leg and torso skin of conscious or anesthetized sheep by using 15-micron radioactive microspheres (Qm) and the /sup 133/Xe washout method (QXe). There was a good relationship between Qm in the cutaneous compartment and QXe calculated from the fast component of the biexponential washout curves (QXe = 0.40.Qm + 6.2, r = 0.90, P less than 0.001) with QXe values substantially below those determined with microspheres. Only at low blood flow levels was there a tendency for QXe to overestimate capillary blood flow as assessed with microspheres, but at higher blood flow levels the /sup 133/Xe washout method resulted in values substantially below those determined with microspheres. The slope of the slow component of the washout curves was inversely related to the tissue-blood partition coefficient in the subcutaneous tissue (r = 0.52, P less than 0.001), indicating an influence of the amount of subcutaneous fat on the washout rate. QXe calculated from the slow component of the washout curves was not significantly correlated with Qm in the subcutaneous compartment (r = 0.19, P greater than 0.10). In leg skin with dilated arteriovenous anastomoses, QXe was generally higher than in torso skin and leg skin withmore » constricted arteriovenous anastomoses, indicating that shunt blood flow increases the washout of /sup 133/Xe.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Univ. of Copenhagen, Denmark
OSTI Identifier:
5840486
Resource Type:
Journal Article
Journal Name:
J. Appl. Physiol.; (United States)
Additional Journal Information:
Journal Volume: 63:3
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; SKIN; BLOOD FLOW; CAPILLARIES; MICROSPHERES; SHEEP; TRACER TECHNIQUES; XENON 133; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DOMESTIC ANIMALS; EVEN-ODD NUCLEI; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NUCLEI; ORGANS; RADIOISOTOPES; RUMINANTS; VERTEBRATES; XENON ISOTOPES; 551001* - Physiological Systems- Tracer Techniques

Citation Formats

Midtgard, U H, Hales, J R, Fawcett, A A, and Sejrsen, P. Skin blood flow in sheep: comparison of xenon-133 washout and radioactive microsphere techniques. United States: N. p., 1987. Web.
Midtgard, U H, Hales, J R, Fawcett, A A, & Sejrsen, P. Skin blood flow in sheep: comparison of xenon-133 washout and radioactive microsphere techniques. United States.
Midtgard, U H, Hales, J R, Fawcett, A A, and Sejrsen, P. 1987. "Skin blood flow in sheep: comparison of xenon-133 washout and radioactive microsphere techniques". United States.
@article{osti_5840486,
title = {Skin blood flow in sheep: comparison of xenon-133 washout and radioactive microsphere techniques},
author = {Midtgard, U H and Hales, J R and Fawcett, A A and Sejrsen, P},
abstractNote = {Blood flow was measured in leg and torso skin of conscious or anesthetized sheep by using 15-micron radioactive microspheres (Qm) and the /sup 133/Xe washout method (QXe). There was a good relationship between Qm in the cutaneous compartment and QXe calculated from the fast component of the biexponential washout curves (QXe = 0.40.Qm + 6.2, r = 0.90, P less than 0.001) with QXe values substantially below those determined with microspheres. Only at low blood flow levels was there a tendency for QXe to overestimate capillary blood flow as assessed with microspheres, but at higher blood flow levels the /sup 133/Xe washout method resulted in values substantially below those determined with microspheres. The slope of the slow component of the washout curves was inversely related to the tissue-blood partition coefficient in the subcutaneous tissue (r = 0.52, P less than 0.001), indicating an influence of the amount of subcutaneous fat on the washout rate. QXe calculated from the slow component of the washout curves was not significantly correlated with Qm in the subcutaneous compartment (r = 0.19, P greater than 0.10). In leg skin with dilated arteriovenous anastomoses, QXe was generally higher than in torso skin and leg skin with constricted arteriovenous anastomoses, indicating that shunt blood flow increases the washout of /sup 133/Xe.},
doi = {},
url = {https://www.osti.gov/biblio/5840486}, journal = {J. Appl. Physiol.; (United States)},
number = ,
volume = 63:3,
place = {United States},
year = {Tue Sep 01 00:00:00 EDT 1987},
month = {Tue Sep 01 00:00:00 EDT 1987}
}